PLG and CXCL2

Number of citations of the paper that reports this interaction (PMID 10928473)
0

Data Source:
HPRD (in vivo)

		PLG	CXCL2
Gene Name		plasminogen	chemokine (C-X-C motif) ligand 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding	Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding
	Biological Process	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Response To Molecule Of Bacterial Origin Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Cell Proliferation Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin
Diseases
GWAS		Aging ( 22773346) Lp (a) levels ( 21900290)	Inflammatory bowel disease ( 23128233) White blood cell count ( 21738479) White blood cell types ( 21738478)
Protein-Protein Interactions		61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1	5 interactors: CXCR1 CXCR2 EPS8 PIK3R1 PLG
Entrez ID		5340	2920
HPRD ID		01417	00741
Ensembl ID		ENSG00000122194	ENSG00000081041
Uniprot IDs		P00747 Q5TEH5	P19875
PDB IDs		1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG	1QNK
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity	Leukocyte Migration Dendritic Cell Migration Interleukin-8-mediated Signaling Pathway Cell Migration Cell Motility Locomotion Movement Of Cell Or Subcellular Component Dendritic Cell Chemotaxis Immune System Process Receptor Internalization Negative Regulation Of Cell-substrate Adhesion Chemokine-mediated Signaling Pathway Vesicle-mediated Transport Receptor Metabolic Process Leukocyte Chemotaxis Endocytosis Negative Regulation Of Neutrophil Apoptotic Process NFAT Protein Import Into Nucleus Cell Activation Cellular Homeostasis Transcription Factor Import Into Nucleus Epidermal Growth Factor Receptor Signaling Pathway Cell Chemotaxis ERBB Signaling Pathway Response To Organic Substance Mononuclear Cell Migration Actin Polymerization-dependent Cell Motility Platelet Activation Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Acute Inflammatory Response To Antigenic Stimulus Exit From Mitosis Cell Surface Receptor Signaling Pathway Defense Response Homeostatic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Behavioral Response To Ethanol Positive Regulation Of Vascular Permeability Response To Stress Positive Regulation Of Cellular Component Movement Metanephric Tubule Morphogenesis Negative Regulation Of Fibrinolysis Positive Regulation Of Locomotion Receptor-mediated Endocytosis Negative Regulation Of Immune System Process Regulation Of Cell-cell Adhesion
Tagcloud ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl5 cxcl6 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf
Tagcloud (Difference) ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl5 cxcl6 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf
Tagcloud (Intersection) ?