SERPINI1 and PLAT

Number of citations of the paper that reports this interaction (PMID 12228252)
13

Data Source:
HPRD (in vivo, in vitro)

		SERPINI1	PLAT
Gene Name		serpin peptidase inhibitor, clade I (neuroserpin), member 1	plasminogen activator, tissue
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Synapse Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Central Nervous System Development Peripheral Nervous System Development Negative Regulation Of Endopeptidase Activity Regulation Of Cell Adhesion	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Synaptic Transmission, Glutamatergic Fibrinolysis Response To Peptide Hormone Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Response To CAMP Transmembrane Transport Positive Regulation Of Ovulation Cellular Response To Dexamethasone Stimulus
Pathways			Signaling by PDGF Dissolution of Fibrin Clot Orphan transporters
Drugs			Urokinase Aminocaproic Acid Ibuprofen Iloprost 6-Amino Hexanoic Acid 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
Diseases
GWAS		Heart rate ( 23534349) Height ( 18391951)
Protein-Protein Interactions		2 interactors: PLAT PLG	25 interactors: ANXA2 CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LAMA5 LRP1 LRP1B MAPK1 MAPK3 PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SPARC
Entrez ID		5274	5327
HPRD ID		03901	01419
Ensembl ID		ENSG00000163536	ENSG00000104368
Uniprot IDs		Q99574	B4DN26 B4DNJ1 P00750
PDB IDs		3F02 3F5N 3FGQ	1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN
Enriched GO Terms of Interacting Partners?		Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Wound Healing Positive Regulation Of Ovulation Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Blood Coagulation Hemostasis Plasminogen Activation Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Fibrinolysis Response To Wounding Regulation Of Fibrinolysis Cell Migration Cell Motility Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Muscle Cell Cellular Homeostasis Smooth Muscle Cell Migration Cellular Response To Dexamethasone Stimulus Positive Regulation Of Blood Coagulation Cell Differentiation Involved In Embryonic Placenta Development Response To Dexamethasone Locomotion Placenta Blood Vessel Development Muscle Cell Migration Positive Regulation Of Coagulation Synaptic Transmission, Glutamatergic Myoblast Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Wound Healing Movement Of Cell Or Subcellular Component Proteolysis Cellular Response To Glucocorticoid Stimulus Tissue Regeneration Negative Regulation Of Cell-substrate Adhesion Cellular Response To Corticosteroid Stimulus Labyrinthine Layer Development Neuron-neuron Synaptic Transmission Transmembrane Transport Platelet Degranulation Extracellular Matrix Disassembly Zymogen Activation Tissue Remodeling Embryonic Placenta Development	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Fibrinolysis Wound Healing Negative Regulation Of Coagulation Platelet Activation Negative Regulation Of Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Cell Migration Regulation Of Blood Coagulation Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Wound Healing Vesicle-mediated Transport Cardiovascular System Development Regulation Of Cell Adhesion Multicellular Organismal Development Developmental Process Cell Activation System Development Anatomical Structure Development Blood Vessel Development Regulation Of Protein Metabolic Process Vasculature Development Regulation Of Vesicle-mediated Transport Regulation Of Catalytic Activity Response To Stress Exocytosis Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis Regulation Of Cellular Protein Metabolic Process Receptor-mediated Endocytosis Response To Stimulus Regulation Of Cell-substrate Adhesion Locomotion Secretion Regulation Of Peptidase Activity Extracellular Matrix Disassembly Blood Vessel Morphogenesis Regulation Of Smooth Muscle Cell-matrix Adhesion Response To External Stimulus Regulation Of Golgi Inheritance Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component
Tagcloud ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine neo1 orbitrap podxl s100a8 secretome silac silico sostdc1 spectrometer tnfsf9 tumorigenic velos zg16b	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Difference) ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine neo1 orbitrap podxl s100a8 secretome silac silico sostdc1 spectrometer tnfsf9 tumorigenic velos zg16b	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Intersection) ?