SERPINB9 and CASP4

Number of citations of the paper that reports this interaction (PMID 10477277)
15

Data Source:
HPRD (in vivo)

		SERPINB9	CASP4
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 9	caspase 4, apoptosis-related cysteine peptidase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome	Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Cysteine-type Endopeptidase Activity
	Biological Process	Mast Cell Mediated Immunity Immune Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Estrogen Stimulus	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Regulation Of Inflammatory Response Execution Phase Of Apoptosis
Pathways			Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: BRD7 C14orf1 CASP4 CCDC90B COPS6 CRMP1 ECH1 EEF1A1 GAPDH GBP2 GDF9 GZMB IGSF21 LRIF1 MED31 PLEKHM1 PRPF40A RBM48 SETDB1 TLE1 TP53 TRAF5 TUBB2A UBR1 UNC119 XRCC6 ZHX1	17 interactors: APAF1 APP CASP1 CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9
Entrez ID		5272	837
HPRD ID		03480	04047
Ensembl ID		ENSG00000170542	ENSG00000196954
Uniprot IDs		P50453	P49662
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To X-ray Negative Regulation Of Fibroblast Proliferation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated RNA Metabolic Process Response To Salt Stress Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression Negative Regulation Of Clathrin-mediated Endocytosis Peptidyl-cysteine S-trans-nitrosylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Neuron Apoptotic Process Cellular Response To Ionizing Radiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitochondrion Organization Metabolic Process Regulation Of RNA Metabolic Process Neuron Death Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Oocyte Growth Oligodendrocyte Apoptotic Process Apoptotic Process Positive Regulation Of Histone Modification Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cellular Process Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cellular Hyperosmotic Salinity Response Cell Death Death Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Response To Osmotic Stress	Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Proteolysis Immune System Process Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Zymogen Activation Protein Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Neuron Apoptotic Process Apoptotic Signaling Pathway Neuron Death Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cell Activation Regulation Of Cell Death Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Signaling Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Cell Communication Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Single Organismal Cell-cell Adhesion Leukocyte Aggregation Defense Response Positive Regulation Of Apoptotic Process Leukocyte Cell-cell Adhesion Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cytokine Production Homotypic Cell-cell Adhesion
Tagcloud ?		administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 cyb5a endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 slc25a29 slc39a14 tgm2 unproven	10mum abeta42 abeta43 aif carnosic cascades casp3 casp8 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Difference) ?		administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 cyb5a endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 slc25a29 slc39a14 tgm2 unproven	10mum abeta42 abeta43 aif carnosic cascades casp3 casp8 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Intersection) ?