PGR and FKBP5

Number of citations of the paper that reports this interaction (PMID 12538866)
35

Data Source:
HPRD (in vivo)

		PGR	FKBP5
Gene Name		progesterone receptor	FK506 binding protein 5
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrial Outer Membrane	Nucleoplasm Endoplasmic Reticulum Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Receptor Binding Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Heat Shock Protein Binding
	Biological Process	Ovulation From Ovarian Follicle Epithelial Cell Maturation Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Gene Expression Negative Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis	Protein Peptidyl-prolyl Isomerization Protein Folding Chaperone-mediated Protein Folding
Pathways		Nuclear signaling by ERBB4 Generic Transcription Pathway Nuclear Receptor transcription pathway Signaling by ERBB4
Drugs		Etonogestrel Desogestrel Megestrol Levonorgestrel Dydrogesterone Progesterone Fluticasone Propionate Medroxyprogesterone Norethindrone Ethynodiol Diacetate Mifepristone Norgestimate Drospirenone Danazol Allylestrenol Methyltrienolone Tanaproget Norelgestromin
Diseases
GWAS
Protein-Protein Interactions		49 interactors: ANP32A APEX2 ARID1A BATF3 BCAS2 BRCA1 CCNA1 CCNA2 CDC25B CDK2 COPS5 CSNK2A1 CUEDC2 DAP3 DDX54 ESR1 FKBP5 HMGB1 HMGB2 JDP2 KAT2B KLF9 NCOA1 NCOA3 NR0B1 PIAS1 PIAS2 PIAS3 POU2F1 POU2F2 PRKDC PRMT2 RBM23 RBM39 RELA RNF4 SMARCD1 SMARCE1 SNW1 SORBS1 SRC TAF1B TDG TRIM24 UBE3A UBR5 XRCC5 XRCC6 ZBTB17	10 interactors: APP CHUK ESR1 FES HSF1 HSP90AA1 IKBKE NR2C2 PGR STIP1
Entrez ID		5241	2289
HPRD ID		07077	04019
Ensembl ID		ENSG00000082175	ENSG00000096060
Uniprot IDs		P06401 Q8TDS3	Q13451 Q2TA84
PDB IDs		1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU	1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM
Enriched GO Terms of Interacting Partners?		Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Androgen Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Hormone Chromosome Organization Regulation Of Cellular Process Chromatin Modification Cellular Response To Stimulus Response To Stimulus Chromatin Organization Cellular Response To Hormone Stimulus Regulation Of Cell Cycle Response To Steroid Hormone Organelle Organization Cellular Response To Organic Substance Intracellular Estrogen Receptor Signaling Pathway	Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Branching Involved In Pregnancy Positive Regulation Of Transcription, DNA-templated Defense Response Steroid Hormone Mediated Signaling Pathway Mammary Gland Epithelium Development Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipid Positive Regulation Of Gene Expression I-kappaB Phosphorylation Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Response To Stimulus System Development Reproduction Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Mammary Gland Development Cellular Response To Steroid Hormone Stimulus Regulation Of Cellular Response To Heat Cellular Response To Stimulus Multicellular Organismal Development Immune Response DNA-templated Transcription, Initiation Anatomical Structure Development Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Reproductive Process Protein Phosphorylation Response To Stress Female Pregnancy Regulation Of Nitric-oxide Synthase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Anatomical Structure Morphogenesis Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Response To Organic Substance Sexual Reproduction Developmental Process Multicellular Organismal Reproductive Process I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		antiperoxidase automatic automatically bauds computerized cutting dab get haemathoxyline immunocytochemistry immunoquantification immunoscore isc obtaining pixel plot recurrences reproducible robustness scene segmentation semilogarithmic simplicity sum summarizes telemedicine telequantification thresholds videophones	12q13 4x10 bd bdi bdnf beck bipolar dbh depression depressive dhh etiology gwas gwass gxe interplay inventory marginally mdd pcorrected personality puncorrected rs4523957 rs7296288 scz slc6a4 sles stressful unsuccessful
Tagcloud (Difference) ?		antiperoxidase automatic automatically bauds computerized cutting dab get haemathoxyline immunocytochemistry immunoquantification immunoscore isc obtaining pixel plot recurrences reproducible robustness scene segmentation semilogarithmic simplicity sum summarizes telemedicine telequantification thresholds videophones	12q13 4x10 bd bdi bdnf beck bipolar dbh depression depressive dhh etiology gwas gwass gxe interplay inventory marginally mdd pcorrected personality puncorrected rs4523957 rs7296288 scz slc6a4 sles stressful unsuccessful
Tagcloud (Intersection) ?