PCNA and SMARCAD1

Number of citations of the paper that reports this interaction (PMID 21549307)
21

Data Source:
BioGRID (fluorescent resonance energy transfer)

		PCNA	SMARCAD1
Gene Name		proliferating cell nuclear antigen	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Cytoplasm Centrosome Nuclear Replication Fork PCNA Complex Extracellular Vesicular Exosome PCNA-p21 Complex	Heterochromatin Nucleoplasm Nuclear Matrix Site Of Double-strand Break Nuclear Replication Fork
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Identical Protein Binding DNA Polymerase Binding	Nucleic Acid Binding DNA Binding Helicase Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Regulation Of DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Heart Development Cell Proliferation Translesion Synthesis Epithelial Cell Differentiation Positive Regulation Of Deoxyribonuclease Activity Telomere Maintenance Via Semi-conservative Replication Response To Lipid Response To Cadmium Ion	Regulation Of DNA Recombination DNA Double-strand Break Processing Chromatin Remodeling Nucleotide Metabolic Process Chromatin Modification ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Protein Homooligomerization Chromosome Separation Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance G1/S Transition Removal of DNA patch containing abasic residue G1/S-Specific Transcription Resolution of Abasic Sites (AP sites) Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Base Excision Repair E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand G0 and Early G1 Telomere C-strand (Lagging Strand) Synthesis S Phase Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS			Capecitabine sensitivity ( 22864933) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		116 interactors: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 EXO1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HLTF HUS1 ING1 KCTD13 LDHA LIG1 MCL1 MLH1 MSH2 MSH3 MSH6 MUTYH MYBBP1A PARP1 PARP10 PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLL POLM PPP1CA PRKDC PTMA RAD18 RAD9A RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RNF8 RPA1 SEC23IP SETD8 SHPRH SIVA1 SMARCAD1 SPRTN SUB1 TCOF1 TDG TIRAP TMEM218 TPI1 UBB UBE2A UBE2B UBE2D3 UHRF2 UNG USP1 USP2 USP4 WDR48 WRN XRCC1 XRCC5 XRCC6 YBX1 ZBTB1	2 interactors: PCNA TRIM28
Entrez ID		5111	56916
HPRD ID		01456	11586
Ensembl ID		ENSG00000132646	ENSG00000163104
Uniprot IDs		P12004	Q9H4L7
PDB IDs		1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3P87 3TBL 3VKX
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Cell Cycle Process Chromosome Organization Base-excision Repair Cellular Metabolic Process Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Recombination Nuclear DNA Replication Mitotic Cell Cycle Mitotic Recombination Mismatch Repair Telomere Maintenance Via Telomere Lengthening DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Strand Elongation Cellular Response To Stimulus Response To Radiation Response To Stimulus Organelle Organization DNA-dependent DNA Replication Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To UV Double-strand Break Repair Nucleotide-excision Repair Response To Abiotic Stimulus Catabolic Process Somatic Diversification Of Immunoglobulins Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Cellular Metabolic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Cycle Response To Light Stimulus Cellular Macromolecule Catabolic Process	Positive Regulation Of DNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of DNA Demethylation Leading Strand Elongation Convergent Extension Involved In Axis Elongation Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development DNA Repair Translesion Synthesis Convergent Extension Negative Regulation Of Viral Release From Host Cell Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Viral Release From Host Cell Nuclear DNA Replication Telomere Maintenance Via Recombination DNA Metabolic Process Protein Sumoylation Epithelium Development Embryonic Placenta Morphogenesis Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Axis Elongation Positive Regulation Of DNA Repair Positive Regulation Of Transcription Factor Import Into Nucleus Transcription-coupled Nucleotide-excision Repair Cellular Response To Stress Epithelial To Mesenchymal Transition Positive Regulation Of Nuclease Activity Response To Cadmium Ion DNA Methylation Mismatch Repair Regulation Of DNA Repair Base-excision Repair Tissue Development Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Viral Process Embryo Implantation Telomere Maintenance DNA Modification Regulation Of Transcription Factor Import Into Nucleus Nucleotide-excision Repair Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA Metabolic Process
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	associates correctly deacetylases deacetylation ensures establishment faithful g9a glp h3k9 hdac1 heterochromatin kap1 machinery marks methyltransferase modulates pcna pericentric perpetuated posttranslational replication repressive repressors segregation silenced snf specify swi
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	associates correctly deacetylases deacetylation ensures establishment faithful g9a glp h3k9 hdac1 heterochromatin kap1 machinery marks methyltransferase modulates pcna pericentric perpetuated posttranslational replication repressive repressors segregation silenced snf specify swi
Tagcloud (Intersection) ?