NOS3 and ST13

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		NOS3	ST13
Gene Name		nitric oxide synthase 3 (endothelial cell)	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Caveola Endocytic Vesicle Membrane	Cytoplasm Cytosol Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Actin Monomer Binding NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Heme Binding Tetrahydrobiopterin Binding Arginine Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding	Protein Binding Protein Domain Specific Binding Hsp70 Protein Binding Protein Binding, Bridging Protein Complex Binding DATP Binding Identical Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Angiogenesis Ovulation From Ovarian Follicle In Utero Embryonic Development Blood Vessel Remodeling Regulation Of Sodium Ion Transport Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Arginine Catabolic Process Nitric Oxide Biosynthetic Process Mitochondrion Organization Nitric Oxide Mediated Signal Transduction Blood Coagulation Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Heat Negative Regulation Of Platelet Activation Negative Regulation Of Muscle Hyperplasia Smooth Muscle Hyperplasia Lung Development Positive Regulation Of Guanylate Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Response To Fluid Shear Stress Negative Regulation Of Potassium Ion Transport Endothelial Cell Migration Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Positive Regulation Of Vasodilation Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Hydrolase Activity Interaction With Host Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Phagosome Maturation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Protein Folding Protein Homooligomerization Negative Regulation Of Protein Refolding Chaperone Cofactor-dependent Protein Refolding
Pathways		Phagosomal maturation (early endosomal stage) VEGFA-VEGFR2 Pathway eNOS activation Metabolism of nitric oxide Platelet homeostasis Signaling by VEGF VEGFR2 mediated vascular permeability NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Latent infection of Homo sapiens with Mycobacterium tuberculosis Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nitric oxide stimulates guanylate cyclase eNOS activation and regulation
Drugs		L-Arginine L-Citrulline Tetrahydrobiopterin Miconazole N,N-dimethylarginine L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide L-2-Amino-4-(Guanidinooxy)Butyric Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N\'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine 1,2,4-Triazole-Carboxamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide S,S\'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 7-Nitroindazole Ethylisothiourea 2-Aminothiazoline Se-Ethyl-Isoselenourea (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane Hydroxydimethylarsine Oxide Heme 7-Nitroindazole-2-Carboxamidine 6-Nitroindazole N-Omega-Hydroxy-L-Arginine N5-Iminoethyl-L-Ornithine 5,6-Cyclic-Tetrahydropteridine S-Ethyl-N-Phenyl-Isothiourea S,S\'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 6s-5,6,7,8-Tetrahydrobiopterin S-(Dimethylarsenic)Cysteine L-Homoarginine S-Isopropyl-Isothiourea Nitroarginine 5-Nitroindazole N-(Chlorophenyl)-N\'-Hydroxyguanidine (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N\'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N\'-(3-chlorobenzyl)ethane-1,2-diamine
Diseases
GWAS
Protein-Protein Interactions		46 interactors: A2M ACTN2 ACTN4 AGTR1 AKT1 APOE APP BDKRB2 BDNF CALM1 CAV1 CDC37 CEP55 EDNRB EFEMP1 EFEMP2 ELAVL1 ELAVL3 EXOC6 EXOSC1 FIS1 GCDH GOLGA2 H3F3A HSP90AA1 HTRA1 IMMT KANK2 MAGEA11 MAST1 MPRIP NMT1 NOSIP NOSTRIN PAXIP1 PI4K2A PPP2R5A PSEN1 PSEN2 RNF31 RNF32 SP1 ST13 TECR TXNDC11 UMPS	18 interactors: ALB APOE ASF1A CD101 CDC42 CTRC CXCR2 F2 HSP90AA1 HSPA1A HSPA4 HSPA8 NOS3 OLFM2 PSEN1 SMAD2 TTR VAV2
Entrez ID		4846	6767
HPRD ID		01224	08426
Ensembl ID		ENSG00000164867	ENSG00000100380
Uniprot IDs		A0S0A6 P29474	B4E0U6 P50502 Q0IJ56
PDB IDs		1M9J 1M9K 1M9M 1M9Q 1M9R 1NIW 2LL7 3EAH 3NOS	1UZS
Enriched GO Terms of Interacting Partners?		Regulation Of Nitric-oxide Synthase Activity Regulation Of Oxidoreductase Activity Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Secretion Cellular Metal Ion Homeostasis Regulation Of Cellular Protein Metabolic Process Cellular Cation Homeostasis Regulation Of Body Fluid Levels Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Regulation Of Cellular Amino Acid Metabolic Process Cellular Homeostasis Response To Abiotic Stimulus Ion Homeostasis Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation Homeostatic Process Hemostasis Reactive Oxygen Species Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Exocytosis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Platelet Degranulation Regulation Of Blood Vessel Size Secretion By Cell Chemical Homeostasis Regulation Of Tube Size Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Metabolic Process Response To Wounding Negative Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ion Transport Wound Healing Establishment Of Localization In Cell Signaling Signal Transduction Negative Regulation Of Protein Phosphorylation Platelet Activation Positive Regulation Of Ion Transport Regulation Of Catalytic Activity Cell Communication Negative Regulation Of Cellular Metabolic Process	Response To External Stimulus Response To Stress Locomotion Negative Regulation Of Platelet Activation Protein Refolding Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Heat Regulation Of Cellular Response To Heat Cellular Response To Stimulus Regulation Of Platelet Activation Positive Regulation Of Immune System Process Anatomical Structure Morphogenesis Regulation Of Wound Healing Response To Unfolded Protein Response To Stimulus Protein Import Into Mitochondrial Outer Membrane Cellular Component Assembly Regulation Of Nitric-oxide Synthase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Vesicle-mediated Transport Regulation Of Apoptotic Process Establishment Of Localization In Cell Movement Of Cell Or Subcellular Component Endocytosis Regulation Of Cell Death Response To Wounding Negative Regulation Of Blood Coagulation Response To Temperature Stimulus Blood Coagulation Negative Regulation Of Coagulation Hemostasis Cellular Response To Heat Negative Regulation Of Wound Healing Regulation Of Cell Morphogenesis Cell Communication Cellular Localization Cell Migration Cell Surface Receptor Signaling Pathway Cell Development Regulation Of Immune System Process Regulation Of Oxidoreductase Activity Secretion By Cell Cardiovascular System Development Anatomical Structure Development Blood Vessel Development Transport Cell Motility Vasculature Development
Tagcloud ?		antidepressants attacks bed favorable genotype genotypes gg glu298asp gt headaches instructed invited medications migraine month night nortriptyline numerical participate polymorphism prophylaxis rating rd st tcas tricyclic tt verbal	carbapenemase centre cpe disseminated dublin ecdc encountered endemic enterobacteriaceae graded implementing intermittent internationally ireland irish klebsiella november outbreak oxa persisted pneumoniae producing pulsed referral sixteen st221 strict typing wards
Tagcloud (Difference) ?		antidepressants attacks bed favorable genotype genotypes gg glu298asp gt headaches instructed invited medications migraine month night nortriptyline numerical participate polymorphism prophylaxis rating rd st tcas tricyclic tt verbal	carbapenemase centre cpe disseminated dublin ecdc encountered endemic enterobacteriaceae graded implementing intermittent internationally ireland irish klebsiella november outbreak oxa persisted pneumoniae producing pulsed referral sixteen st221 strict typing wards
Tagcloud (Intersection) ?