NFYC and CSN2

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		NFYC	CSN2
Gene Name		nuclear transcription factor Y, gamma	casein beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex	Extracellular Region Extracellular Space
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	Enzyme Inhibitor Activity Transporter Activity Calcium Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Folding Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated	Calcium Ion Transport Lactation Negative Regulation Of Catalytic Activity
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins ATF4 activates genes ATF6-alpha activates chaperone genes Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) PERK regulates gene expression ATF6-alpha activates chaperones Unfolded Protein Response (UPR)	Nuclear signaling by ERBB4 Signaling by ERBB4
Drugs
Diseases
GWAS		Platelet counts ( 21507922)
Protein-Protein Interactions		27 interactors: ADNP2 ARID2 ATF6 ATF6B CIC CSN2 DR1 DST GAPDH GLTSCR1 GLTSCR1L KIAA2018 LMO4 MYC NFYA NFYB POGZ SMAD2 SMAD3 SNX2 SP1 SREBF2 TAF11 TAF12 TAF6 TBP ZDHHC17	17 interactors: AURKA CDC42 CDK1 CELA1 CSN3 CSNK2A1 CSNK2B FHL2 GRB2 HTRA2 NEK1 NEK2 NEK8 NFYC PLK1 RAC1 TOLLIP
Entrez ID		4802	1447
HPRD ID		05633	00281
Ensembl ID		ENSG00000066136	ENSG00000135222
Uniprot IDs		Q13952	P05814
PDB IDs		1N1J 4AWL
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Gene Expression Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Primary MiRNA Processing Viral Process Regulation Of Nodal Signaling Pathway Cellular Metabolic Process SMAD Protein Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Paraxial Mesoderm Morphogenesis Positive Regulation By Host Of Viral Transcription Positive Regulation Of Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Nuclear Division Developmental Process Cell Projection Morphogenesis Cell Part Morphogenesis Mitotic Nuclear Division Regulation Of Organelle Organization Anatomical Structure Morphogenesis Neuron Development Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Axon Guidance Mitotic Cell Cycle Process Cell Morphogenesis Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Cell Division Neuron Differentiation Regulation Of Protein Metabolic Process Cell Projection Organization Centrosome Organization Regulation Of Cell Division Neuron Projection Development Regulation Of Binding Multicellular Organismal Development Microtubule Organizing Center Organization Positive Regulation Of Signal Transduction Wnt Signaling Pathway Cell Development Axonogenesis Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Phosphorylation Cell Cycle Positive Regulation Of Protein Modification Process Cellular Protein Catabolic Process Regulation Of Cell Cycle Axon Development Regulation Of Metabolic Process Mitotic Nuclear Envelope Disassembly System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Stability Chemotaxis
Tagcloud ?		associates attempt blastocyst cdc25a cdc42 egg embryonal esg1 exist forced icm immediately immunoprecipitated inner kh notion nr5a2 oct3 overlap pluripotency polar pou5f1 preimplantation supporting te transcript transcriptase transcripts trophectoderm	0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn1s csn1s1 csn1s2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true
Tagcloud (Difference) ?		associates attempt blastocyst cdc25a cdc42 egg embryonal esg1 exist forced icm immediately immunoprecipitated inner kh notion nr5a2 oct3 overlap pluripotency polar pou5f1 preimplantation supporting te transcript transcriptase transcripts trophectoderm	0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn1s csn1s1 csn1s2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true
Tagcloud (Intersection) ?