NFATC2 and IRF2BP2

Number of citations of the paper that reports this interaction (PMID 21576369)
3

Data Source:
BioGRID (pull down)

		NFATC2	IRF2BP2
Gene Name		nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	interferon regulatory factor 2 binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Ribonucleoprotein Complex Nuclear Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cytokine Production Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Cell Migration Positive Regulation Of B Cell Proliferation Fc-epsilon Receptor Signaling Pathway Response To Drug Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter B Cell Receptor Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System
Drugs
Diseases
GWAS			Bipolar disorder ( 22688191) Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Life threatening arrhythmia ( 22247754)
Protein-Protein Interactions		19 interactors: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 JUN MED31 MEF2D NFATC2IP PIN1 PPP3CB PPP3R1 PRKCZ TAF9 VIM YWHAQ YWHAZ	2 interactors: IRF2 NFATC2
Entrez ID		4773	359948
HPRD ID		02730	17160
Ensembl ID		ENSG00000101096	ENSG00000168264
Uniprot IDs		B5B2P0 B5B2P2 B5B2P3 B5B2P4 Q13469	Q7Z5L9
PDB IDs		1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Immune Response Regulation Of Metabolic Process Defense Response Innate Immune Response Positive Regulation Of Interleukin-4 Production Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Signaling Cell Activation Regulation Of Interleukin-4 Production Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Leukocyte Activation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Regulation Of Signal Transduction Gene Expression Regulation Of CD4-positive, Alpha-beta T Cell Differentiation N-terminal Peptidyl-lysine Acetylation Histone Acetylation Regulation Of Cellular Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Cytokine Production Internal Protein Amino Acid Acetylation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Acetylation Leukocyte Differentiation Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Apoptotic Process Apoptotic Signaling Pathway T Cell Differentiation Positive Regulation Of Cytokine Production RNA Metabolic Process Regulation Of Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Immune Response Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Defense Response B Cell Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Positive Regulation Of B Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of B Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of B Cell Activation Negative Regulation Of Cellular Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Transcription, DNA-templated Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation RNA Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Antigen Receptor-mediated Signaling Pathway Cytokine Production Positive Regulation Of Cellular Metabolic Process Cellular Response To Interferon-gamma Response To Interferon-gamma Cell Surface Receptor Signaling Pathway RNA Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Gene Expression Fc Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Macromolecule Biosynthetic Process Positive Regulation Of Cell Activation
Tagcloud ?		calcineurin deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf	apl arsenic breakpoints consolidation cytogenetics ecchymoses epistaxis exon expands fusion gemtuzumab immunophenotypic intron list morphologic next oligonucleotide ozogamicin partners pml presents promyelocytic rara rarely relapsed remission sequencing translocations woman
Tagcloud (Difference) ?		calcineurin deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf	apl arsenic breakpoints consolidation cytogenetics ecchymoses epistaxis exon expands fusion gemtuzumab immunophenotypic intron list morphologic next oligonucleotide ozogamicin partners pml presents promyelocytic rara rarely relapsed remission sequencing translocations woman
Tagcloud (Intersection) ?