NF1 and DNAJC7

Number of citations of the paper that reports this interaction (PMID 8836031)
8

Data Source:
HPRD (in vivo)

		NF1	DNAJC7
Gene Name		neurofibromin 1	DnaJ (Hsp40) homolog, subfamily C, member 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Membrane Axon Dendrite Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane	Nucleoplasm Cytoplasm Cytoskeleton Membrane Extracellular Vesicular Exosome
	Molecular Function	Ras GTPase Activator Activity Protein Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding	Protein Binding Heat Shock Protein Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Communication Ras Protein Signal Transduction Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Skeletal Muscle Tissue Development Visual Learning Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Schwann Cell Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Spinal Cord Development Forebrain Astrocyte Development Neural Tube Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Adrenal Gland Development Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Regulation Of Ras GTPase Activity Positive Regulation Of Ras GTPase Activity Negative Regulation Of Rac Protein Signal Transduction Wound Healing Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Bone Resorption Negative Regulation Of Osteoclast Differentiation Regulation Of Glial Cell Differentiation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Angiogenesis Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotransmitter Secretion Negative Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Sympathetic Nervous System Development Camera-type Eye Morphogenesis Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Artery Morphogenesis Forebrain Morphogenesis Cognition Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Folding Chaperone Cofactor-dependent Protein Refolding
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: APP DNAJC7 FAF2 GRIN1 GRIN2D HRAS MYOG SDC2 SMAD2 SMAD3 SMAD4 TBPL1 VCP	14 interactors: DISC1 HSP90AA1 HSPA1A HSPA8 HUS1 MKNK1 NF1 RAD1 RAD9A SMAD2 SMAD9 SMURF1 TP53 UBE4B
Entrez ID		4763	7266
HPRD ID		01203	07046
Ensembl ID		ENSG00000196712	ENSG00000168259
Uniprot IDs		P21359	Q99615
PDB IDs		1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex Assembly Response To Abiotic Stimulus Cell Development Regulation Of Cell Development Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Axon Guidance Cellular Component Assembly Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Stem Cell Differentiation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Primary MiRNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Glutamate Receptor Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Gene Expression Axonogenesis Visual Behavior Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Cellular Response To Growth Factor Stimulus Protein Complex Assembly Axon Development Endoderm Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Embryonic Pattern Specification Response To Growth Factor Cell Differentiation Regulation Of Transforming Growth Factor Beta2 Production Paraxial Mesoderm Morphogenesis Chemotaxis Developmental Growth Associative Learning Positive Regulation Of Cellular Metabolic Process Neuron Projection Morphogenesis Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Ephrin Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation	Response To Abiotic Stimulus Cellular Response To Stimulus Cellular Response To Ionizing Radiation Response To Radiation Protein Refolding Response To Stimulus Regulation Of Cellular Response To Heat Cellular Response To Radiation Transforming Growth Factor Beta Receptor Signaling Pathway Response To Ionizing Radiation DNA Damage Checkpoint Response To Stress Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Neuroblast Proliferation Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Heat Cell Cycle Checkpoint Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Stress Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Light Stimulus Regulation Of Stem Cell Proliferation Response To Heat Apoptotic Signaling Pathway Brain Development Response To UV Anatomical Structure Development Response To Unfolded Protein Head Development Regulation Of Cellular Process Cellular Macromolecule Catabolic Process Negative Regulation Of Neuroblast Proliferation Mitotic Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Cell Surface Receptor Signaling Pathway Regulation Of Cell Cycle Cellular Metabolic Process Nervous System Development Regulation Of Cell Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Stem Cell Proliferation Developmental Process
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink pepa pig prkca rara representatives sheep southern swine synteny tk1 umph2
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink pepa pig prkca rara representatives sheep southern swine synteny tk1 umph2
Tagcloud (Intersection) ?