NEDD4 and SNCA

Number of citations of the paper that reports this interaction (PMID 21953697)
13

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, enzymatic study)

		NEDD4	SNCA
Gene Name		neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	synuclein, alpha (non A4 component of amyloid precursor)
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Apicolateral Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Lysosome Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Ribosome Plasma Membrane Cell Cortex Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon Growth Cone Platelet Alpha Granule Membrane Terminal Bouton Fibril Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ligase Activity Sodium Channel Inhibitor Activity Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ubiquitin Binding Phosphoserine Binding Phosphothreonine Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding	Magnesium Ion Binding Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Microtubule Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Kinesin Binding Protein Domain Specific Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Phospholipase Binding Transcription Regulatory Region DNA Binding Dynein Binding Protein N-terminus Binding Tau Protein Binding Beta-tubulin Binding Phosphoprotein Binding Phospholipase D Inhibitor Activity
	Biological Process	Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Protein Monoubiquitination Protein Targeting To Lysosome Lysosomal Transport Neuromuscular Junction Development Negative Regulation Of Sodium Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination Transmission Of Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV Regulation Of Ion Transmembrane Transport T Cell Activation Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Glucocorticoid Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Development Involved In Symbiotic Interaction Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Microglial Cell Activation Positive Regulation Of Receptor Recycling Negative Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Fatty Acid Metabolic Process Neutral Lipid Metabolic Process Phospholipid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Membrane Organization Aging Adult Locomotory Behavior Response To Iron(II) Ion Regulation Of Phospholipase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Negative Regulation Of Transporter Activity Response To Lipopolysaccharide Negative Regulation Of Monooxygenase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Interferon-gamma Cellular Response To Oxidative Stress Negative Regulation Of Histone Acetylation Regulation Of Locomotion Dopamine Biosynthetic Process Response To Drug Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extracellular Fibril Organization Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Negative Regulation Of Dopamine Metabolic Process Behavioral Response To Cocaine Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synapse Organization Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Oxidation-reduction Process Regulation Of Excitatory Postsynaptic Membrane Potential Long-term Synaptic Potentiation Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		Downregulation of ERBB4 signaling Antigen processing: Ubiquitination & Proteasome degradation ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Adaptive Immune System	Amyloids
Drugs
Diseases
GWAS		Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 20062064) Keloid ( 20711176)	Parkinson's disease ( 22451204 20711177 21084426 21292315 19915575 19915576 22438815 20070850 21044948 21738487)
Protein-Protein Interactions		215 interactors: ABL1 ABL2 ADRB2 AKT3 AMOT AMOTL1 AMPD2 ANKRD13D ANXA13 AP1G2 ARID1A ARRDC1 ARRDC3 ASPSCR1 AURKC BAIAP2 BECN1 BMPR1A BRCA2 C11orf63 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CUEDC1 DAZAP2 DCUN1D1 DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EPHA5 EPRS EPS15 ERBB3 ERBB4 ERMN FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FYN GBA GRB10 GRIN2A GRK4 GRK7 HGS HMCES HNRNPK HNRNPL HNRNPU HNRNPUL1 IGF1R IRS1 JUN KCNAB1 KCNAB2 KIAA1598 KIFC3 LAPTM5 LATS1 LITAF LUC7L2 MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MTMR4 MYCN N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NSRP1 NTRK1 NUDT21 PARP16 PDGFRB PKN2 PLK1 PLK2 PMEPA1 POLR2A POLR2B POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRRG1 PRRG2 PSMD4 PTEN RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RFT1 RNF11 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEPT9 SFTPC SGK1 SGK2 SH3KBP1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 SULF1 SYK SYT1 TAF1B TBC1D7 TBK1 TCEANC TCP11L1 TEAD2 THRAP3 TNIK TOM1 TOM1L2 TP73 TRIM44 TRIM52 TRPV6 TSTA3 TTYH2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2M UBOX5 URI1 WBP1 WBP2 WEE1 WIBG YES1 YOD1	110 interactors: A1BG ACTA1 ADAP2 ADRBK1 AKT1 ANXA6 APLP1 APP ARHGAP15 ARPP19 BAD BAG5 BAX BCL2L1 BDH2 CALM1 CAV1 CDC42EP2 CDC42EP3 CDC42SE1 CDK4 COL25A1 COX1 COX3 CRYAB CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CTNND1 CYCS DMTN DOCK7 DYNC1H1 DYRK1A EEF1A1 EIF3G ELK1 ENC1 ENSA FGR FKBP4 FYN GABARAPL1 GAPDH GRK1 GRK5 GRK6 GSK3B HSD17B4 HSP90AA1 HSPA1A HSPA8 HSPB1 HSPB2 HSPB6 HSPB8 IARS KIAA1191 KLC1 KLK6 LYN MAP1B MAPK1 MAPK8IP1 MAPT MEF2D NEDD4 NEDD4L PAK3 PARK2 PDE4DIP PELP1 PFDN2 PINK1 PLCB2 PLD1 PLK1 PLK2 PLK3 PRDX1 PRKCE PTK2B RABAC1 RNF10 SAP30BP SDF4 SEPT4 SIAH1 SIAH2 SLC6A3 SNCAIP SNCB SPTBN1 SQSTM1 SRC SRI SUMO2 SYK SYN1 TGM1 TH TOR1A TUBA1A UBB UBC USP47 YWHAB YWHAE YWHAH
Entrez ID		4734	6622
HPRD ID		03786	01227
Ensembl ID		ENSG00000069869	ENSG00000145335
Uniprot IDs		P46934	H6UYS0 H6UYS5 P37840
PDB IDs		2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Phosphorylation Response To Growth Factor Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cell Communication Cellular Protein Modification Process Regulation Of Phosphorylation Signal Transduction Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Death Regulation Of Metabolic Process Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Cellular Component Organization Regulation Of Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Cellular Metabolic Process Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification	Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Localization Cell Death Death Regulation Of Cell Death Apoptotic Process Response To Abiotic Stimulus Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Intracellular Transport Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Proteolysis Positive Regulation Of Metabolic Process Response To Organic Substance Negative Regulation Of Apoptotic Process Nervous System Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stimulus System Development Negative Regulation Of Protein Metabolic Process Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Response To Stress Negative Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Death Cell Communication Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Signaling Intracellular Signal Transduction Positive Regulation Of Proteolysis Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To External Stimulus Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins ww	2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically prdx2 predictedinteractions scrutinized searching slowing string sum tof
Tagcloud (Difference) ?		accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins ww	2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically prdx2 predictedinteractions scrutinized searching slowing string sum tof
Tagcloud (Intersection) ?