NBN and RECQL5

Number of citations of the paper that reports this interaction (PMID 19270065)
16

Data Source:
BioGRID (pull down)

		NBN	RECQL5
Gene Name		nibrin	RecQ protein-like 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body	Nucleus Nucleoplasm Nucleolus Cytoplasm DNA-directed RNA Polymerase II, Holoenzyme Nuclear Membrane
	Molecular Function	Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding Transcription Factor Binding Protein N-terminus Binding	RNA Polymerase II Core Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding ATP-dependent Helicase Activity
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Blastocyst Growth DNA Repair Double-strand Break Repair Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Mitotic G2 DNA Damage Checkpoint Cell Proliferation Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Intrinsic Apoptotic Signaling Pathway	DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Mitotic Nuclear Division DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cell Division Chromosome Separation
Pathways		ATM mediated phosphorylation of repair proteins Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci ATM mediated response to DNA double-strand break Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ATF2 ATM ATR BRCA1 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AFX MDC1 MRE11A NCL PRKDC RAD18 RAD50 RECQL5 RNF8 SIRT1 TERF1 TLK1 TREX1 UBE2D1 UBE2N XRCC4 XRCC5	19 interactors: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11A MTSS1 NBN PLK1 POLR2A RAD50 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		4683	9400
HPRD ID		04050	04806
Ensembl ID		ENSG00000104320	ENSG00000108469
Uniprot IDs		O60934	B3KQK2 O94762 Q6P4G0 Q8WYH5
PDB IDs			4BK0
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair DNA Recombination Response To Ionizing Radiation Response To Stress Cell Cycle Process Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Response To Radiation Cell Cycle Checkpoint Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Damage Checkpoint DNA Replication Telomere Maintenance Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Response To DNA Damage Stimulus Cellular Response To Stimulus Mitotic Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Organelle Organization Response To Stimulus Response To Gamma Radiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of DNA Repair Negative Regulation Of Mitotic Cell Cycle Intra-S DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Repair Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of DNA Replication Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process	DNA Conformation Change Positive Regulation Of Protein Autophosphorylation Meiotic Cell Cycle Regulation Of Protein Autophosphorylation G2 DNA Damage Checkpoint Chromosome Organization Cellular Response To Stress Meiotic Nuclear Division Regulation Of Mitotic Recombination Telomere Maintenance Telomere Maintenance Via Telomerase DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Mitotic G2 DNA Damage Checkpoint Cell Cycle Process DNA Metabolic Process Mitotic Cell Cycle Process DNA Topological Change RNA-dependent DNA Replication Organelle Organization Double-strand Break Repair Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Kinase Activity Mitotic Cell Cycle Checkpoint Telomere Maintenance Via Telomere Lengthening Cellular Response To DNA Damage Stimulus Response To Stress Mitotic Cytokinesis Reciprocal Meiotic Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation Cell Cycle Checkpoint DNA Recombination Positive Regulation Of Transferase Activity Reproduction DNA Repair Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of DNA Recombination Cellular Nitrogen Compound Metabolic Process Activation Of APC-Cdc20 Complex Activity Transcription, RNA-templated Glycine Betaine Biosynthetic Process From Choline Adherens Junction Maintenance Positive Regulation Of Cellular Metabolic Process Cell Proliferation
Tagcloud ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Difference) ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Intersection) ?