MYD88 and IRAK4

Number of citations of the paper that reports this interaction (PMID 11960013)
100

Data Source:
HPRD (in vivo, in vitro)

		MYD88	IRAK4
Gene Name		myeloid differentiation primary response 88	interleukin-1 receptor-associated kinase 4
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Endosome Membrane	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Death Receptor Binding Protein Binding Identical Protein Binding TIR Domain Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Mechanical Stimulus	Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation JNK Cascade Cytokine-mediated Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation
Pathways		p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Innate Immune System
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted TNF-alpha) ( 22610502)
Protein-Protein Interactions		39 interactors: BTK CD93 CISH FADD FLII IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 PELI2 PFKL POLR1C PRDX1 RAC1 SARM1 SIAH1 SIAH2 SMAD3 SPOP STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7	18 interactors: ARNT EIF4EBP1 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H1T IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6
Entrez ID		4615	51135
HPRD ID		03703	06051
Ensembl ID		ENSG00000172936	ENSG00000198001
Uniprot IDs		J3KPU4 J3KQ87 J3KQJ6 Q99836	B2RAP9 B4E359 Q69FE3 Q9NWZ3
PDB IDs		2JS7 2Z5V 3MOP 4DOM 4EO7	2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Defense Response Regulation Of Cytokine Production Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Interferon-beta Production Response To Other Organism I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Regulation Of Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Biotic Stimulus Toll-like Receptor 2 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Regulation Of Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of Interferon-beta Production Regulation Of Intracellular Signal Transduction Response To External Stimulus Inflammatory Response Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Chemokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Interferon-alpha Production Regulation Of Protein Metabolic Process Signal Transduction Response To Stimulus Regulation Of Chemokine Production	Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nucleosome Assembly Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Chromatin Assembly Nucleosome Organization Toll-like Receptor 9 Signaling Pathway Response To Bacterium Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Cytokine Production DNA Packaging Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Nucleosome Positioning Response To Other Organism Immune Response-regulating Signaling Pathway Response To Biotic Stimulus DNA Conformation Change Positive Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Regulation Of Immune System Process Defense Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Response Protein Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Lymphocyte Proliferation Response To Lipid
Tagcloud ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un	curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Difference) ?		binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un	curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Intersection) ?