MYB and PAX5

Number of citations of the paper that reports this interaction (PMID 11781241)
8

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MYB	PAX5
Gene Name		v-myb avian myeloblastosis viral oncogene homolog	paired box 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Nuclear Matrix	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding WD40-repeat Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Calcium Ion Transport Blood Coagulation B Cell Differentiation Positive Regulation Of T-helper Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Embryonic Digestive Tract Development Homeostasis Of Number Of Cells Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K9 Methylation Cellular Response To Interleukin-6	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Humoral Immune Response Multicellular Organismal Development Spermatogenesis Nervous System Development Organ Morphogenesis Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Histone H3-K9 Methylation
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929) HbA2 levels ( 23043469) Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular hemoglobin concentration ( 23263863 20139978) Mean corpuscular volume ( 23263863 20139978 19862010) Mean platelet volume ( 22423221) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet counts ( 22139419 20139978) Red blood cell count ( 20139978) Red blood cell traits ( 20927387) White blood cell count ( 20139978) White blood cell types ( 21738478)	Intelligence ( 22449649) Obesity and blood pressure ( 22013104)
Protein-Protein Interactions		43 interactors: BTRC CCND3 CEBPB CEBPE CHD3 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAX5 PIAS1 PML PPM1K RBX1 RPL4 RQCD1 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11	14 interactors: CREBBP DAXX EBF1 EP300 ETS1 ID2 ID3 KPNA1 KPNA2 MYB RB1 RUNX1 TBP TLE4
Entrez ID		4602	5079
HPRD ID		01810	01334
Ensembl ID		ENSG00000118513	ENSG00000196092
Uniprot IDs		P10242 Q14025 Q708E1 Q708E9	C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548
PDB IDs			1K78 1MDM
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Protein Sumoylation Cellular Protein Modification Process Rhythmic Process Protein Modification By Small Protein Conjugation Developmental Process Peptidyl-lysine Modification PML Body Organization Cell Cycle Regulation Of Signal Transduction Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Viral Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Metabolic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cell Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Chromatin Modification Positive Regulation Of Macrophage Differentiation N-terminal Protein Amino Acid Acetylation Rhythmic Process Embryo Development Mitotic Cell Cycle Process
Tagcloud ?		amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic lck leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates	aldo aldob aldolase ambp anchor anonymous backcross bikunin d4h9s3e d4nds4 d9s3 dehydratase galt hexabrachion homologues hsa9 hsa9q hxb ifa interspecific levulinate localizations mmu4 orm orosomucoid synteny typed tyrp
Tagcloud (Difference) ?		amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic lck leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates	aldo aldob aldolase ambp anchor anonymous backcross bikunin d4h9s3e d4nds4 d9s3 dehydratase galt hexabrachion homologues hsa9 hsa9q hxb ifa interspecific levulinate localizations mmu4 orm orosomucoid synteny typed tyrp
Tagcloud (Intersection) ?