MVD and GNB5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MVD	GNB5
Gene Name		mevalonate (diphospho) decarboxylase	guanine nucleotide binding protein (G protein), beta 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Peroxisome Cytosol	Nucleus Plasma Membrane
	Molecular Function	Diphosphomevalonate Decarboxylase Activity ATP Binding Hsp70 Protein Binding Protein Homodimerization Activity	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Cell Proliferation Isoprenoid Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Regulation of cholesterol biosynthesis by SREBP (SREBF) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Synthesis of Dolichyl-phosphate Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Cholesterol biosynthesis Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Activation of gene expression by SREBF (SREBP) Diseases associated with N-glycosylation of proteins	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BTAF1 EEF1G EIF4EBP1 GNB5 HSPA9	26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		4597	10681
HPRD ID		04454	09191
Ensembl ID		ENSG00000167508	ENSG00000069966
Uniprot IDs		P53602	B3KWS4 O14775
PDB IDs		3D4J
Enriched GO Terms of Interacting Partners?			Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway
Tagcloud ?		aggressive analyse bcc behavior carcinomas exceeded explain fact immunohistochemically indicator ka keratoacanthomas metastatic microvessel neoplasms nod nodular paraffin perilesional psmvd scc scl sclerosing sections slow stained tmvd vascularized viii
Tagcloud (Difference) ?		aggressive analyse bcc behavior carcinomas exceeded explain fact immunohistochemically indicator ka keratoacanthomas metastatic microvessel neoplasms nod nodular paraffin perilesional psmvd scc scl sclerosing sections slow stained tmvd vascularized viii
Tagcloud (Intersection) ?