MTTP and APOB

Number of citations of the paper that reports this interaction (PMID 11358959)
7

Data Source:
HPRD (in vivo, two hybrid)

		MTTP	APOB
Gene Name		microsomal triglyceride transfer protein	apolipoprotein B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Actin Cytoskeleton Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Lipid Transporter Activity Lipid Binding	Protein Binding Phospholipid Binding Heparin Binding Cholesterol Transporter Activity Lipase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Lipoprotein Metabolic Process Small Molecule Metabolic Process	Retinoid Metabolic Process In Utero Embryonic Development Triglyceride Mobilization Receptor-mediated Endocytosis Spermatogenesis Nervous System Development Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Fertilization Response To Virus Response To Carbohydrate Post-embryonic Development Response To Selenium Ion Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Cholesterol Transport Sperm Motility Response To Lipopolysaccharide Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Small Molecule Metabolic Process Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Leukocyte Migration Transmembrane Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin Stimulus
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport	Lipoprotein metabolism LDL-mediated lipid transport Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Cell surface interactions at the vascular wall Platelet homeostasis Visual phototransduction Scavenging by Class H Receptors Platelet sensitization by LDL Scavenging by Class F Receptors Scavenging by Class A Receptors Scavenging by Class B Receptors Orphan transporters Retinoid metabolism and transport
Drugs		Hesperetin Lomitapide
Diseases
GWAS			Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Erectile dysfunction and prostate cancer treatment ( 20932654) HDL cholesterol ( 20864672 19060911 20686565) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18262040 23726366 21059979 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Response to statin therapy ( 20339536) Triglycerides ( 18193044 20864672 19060906 19060911 17463246 20686565)
Protein-Protein Interactions		2 interactors: APOB HSP90B1	22 interactors: AKT2 APOA1 ARFGAP1 BGN CALR CANX HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3
Entrez ID		4547	338
HPRD ID		01144	00133
Ensembl ID		ENSG00000138823	ENSG00000084674
Uniprot IDs		E9PBP6 P55157	P04114 Q59HB3 Q7Z7Q0
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Rod Assembly Receptor-mediated Endocytosis Sequestering Of Calcium Ion Response To Selenium Ion Very-low-density Lipoprotein Particle Assembly Protein Catabolic Process Triglyceride Mobilization Cellular Response To ATP Endocytosis Sequestering Of Metal Ion Low-density Lipoprotein Particle Remodeling Chemical Homeostasis Lipoprotein Catabolic Process Protein-lipid Complex Assembly Positive Regulation Of Cholesterol Storage Cellular Response To Prostaglandin Stimulus Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Triglyceride Catabolic Process Low-density Lipoprotein Particle Clearance Acylglycerol Catabolic Process Response To Abiotic Stimulus Response To ATP Plasma Lipoprotein Particle Remodeling Cholesterol Efflux Regulation Of Cholesterol Metabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Regulation Of Phosphoprotein Phosphatase Activity Plasma Lipoprotein Particle Clearance ER-associated Ubiquitin-dependent Protein Catabolic Process Homeostatic Process Protein Transport Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Fatty Acid Vesicle-mediated Transport Establishment Of Protein Localization Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Artery Morphogenesis Sperm Motility Regulation Of Lipid Storage Regulation Of Plasma Lipoprotein Particle Levels Artery Development Sterol Transport Cholesterol Transport Catabolic Process Response To Fatty Acid Regulation Of Steroid Biosynthetic Process Cellular Response To Organic Substance	Protein Folding Response To Unfolded Protein Receptor-mediated Endocytosis Protein Metabolic Process Chaperone-mediated Protein Folding Transport Cellular Protein Metabolic Process Vesicle-mediated Transport Protein Stabilization Plasma Lipoprotein Particle Clearance Endocytosis Regulation Of Protein Stability Protein Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Establishment Of Protein Localization Protein Localization Regulation Of Plasma Lipoprotein Particle Levels Response To Endoplasmic Reticulum Stress Establishment Of Localization In Cell Cholesterol Transport Sterol Transport Protein Refolding Cholesterol Homeostasis Sterol Homeostasis Endoplasmic Reticulum Unfolded Protein Response Homeostatic Process Cellular Response To Unfolded Protein Cholesterol Import Cellular Localization Regulation Of Protein Phosphorylation Posttranscriptional Regulation Of Gene Expression ER-nucleus Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Cellular Response To Topologically Incorrect Protein Response To Abiotic Stimulus Cellular Metabolic Process Lipid Homeostasis Cellular Response To Stress Response To Organic Substance Sequestering Of Calcium Ion Positive Regulation Of Cellular Metabolic Process Secretion By Cell Lipid Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Chemical Homeostasis Lipid Localization Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Phosphorylation
Tagcloud ?		apob atherosclerosis atherosclerotic causality esters flox foam inference inherited ldlr master mature mll5 mx1 networks pcl pparg regressed regression regulators remnants responding slows sometimes srsf10 tf thp unstable xrn2	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Difference) ?		atherosclerosis atherosclerotic causality esters flox foam inference inherited ldlr master mature mll5 mx1 networks pcl pparg regressed regression regulators remnants responding slows sometimes srsf10 tf thp unstable xrn2	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Intersection) ?		apob