MST1 and FOXO1

Number of citations of the paper that reports this interaction (PMID 18786403)
26

Data Source:
BioGRID (enzymatic study)

		MST1	FOXO1
Gene Name		macrophage stimulating 1 (hepatocyte growth factor-like)	forkhead box O1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Molecular_function Serine-type Endopeptidase Activity	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding
	Biological Process	Proteolysis Spermatogenesis Embryo Implantation Biological_process Sperm Motility	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Temperature Homeostasis Cellular Glucose Homeostasis Transcription From RNA Polymerase II Promoter Protein Acetylation Autophagy Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Starvation Positive Regulation Of Autophagy Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Cold Cellular Response To Hyperoxia Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Energy Homeostasis
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Regulation of beta-cell development PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Regulation of gene expression in beta cells Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 18587394 17554261 17554300 21102463) Inflammatory bowel disease ( 23128233) Primary sclerosing cholangitis ( 21151127) Ulcerative colitis ( 19915572 20228799 21297633)	Central corneal thickness ( 20485516 20719862) Corneal structure ( 23291589)
Protein-Protein Interactions		8 interactors: DAXX FOXO1 HIST2H2BE KLKB1 MOB1A MST1R RASSF1 SERPINA3	31 interactors: AKT1 AR CEBPB CREBBP CSNK1G1 CTNNB1 DYRK1A EP300 ESR1 FHL2 FOXG1 G6PC GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 PAK1 PARP1 PPARG RARA SIRT1 SMAD3 SMAD4 SRC THRB TXNRD1 YWHAG YWHAZ
Entrez ID		4485	2308
HPRD ID		00798	00645
Ensembl ID		ENSG00000173531	ENSG00000150907
Uniprot IDs		G3XAK1 P26927 Q53GN8	Q12778
PDB IDs		2ASU	3CO6 3CO7 3COA
Enriched GO Terms of Interacting Partners?		Response To Stress Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response Response To Stimulus Acute Inflammatory Response Factor XII Activation Nucleosome Assembly Chromatin Assembly Regulation Of MAPK Cascade Macrophage Colony-stimulating Factor Signaling Pathway Nucleosome Organization Chromatin Assembly Or Disassembly Positive Regulation Of Fibrinolysis Protein-DNA Complex Assembly DNA Packaging Regulation Of Stress-activated MAPK Cascade Innate Immune Response Regulation Of Protein Ubiquitination Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Cellular Response To Cold Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Macrophage Colony-stimulating Factor Stimulus Multicellular Organismal Homeostasis Positive Regulation Of Protein Modification Process Plasminogen Activation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Plasma Kallikrein-kinin Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Conformation Change Regulation Of Energy Homeostasis Regulation Of MAP Kinase Activity Cellular Response To Nitric Oxide Regulation Of Fibrinolysis Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation, Intrinsic Pathway Maintenance Of Gastrointestinal Epithelium Response To Nitric Oxide Innate Immune Response In Mucosa Positive Regulation Of Gluconeogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Processing Epithelial Structure Maintenance Immune Response Regulation Of Phosphorylation Regulation Of Protein Processing Cellular Response To Reactive Nitrogen Species	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Hormone Positive Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Death Multicellular Organismal Development Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Anatomical Structure Development Regulation Of RNA Metabolic Process Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Apoptotic Process RNA Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process System Development Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Developmental Process Organ Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Gene Expression Regulation Of Signaling Tissue Development Regulation Of Protein Localization Regulation Of Metabolic Process Reproductive Structure Development Epithelium Development Reproductive System Development Transcription From RNA Polymerase II Promoter Regulation Of Establishment Of Protein Localization Epithelial Cell Differentiation Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mbp mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad	adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pca pi3k restriction subcellular transfections woundhealing wst
Tagcloud (Difference) ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mbp mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad	adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pca pi3k restriction subcellular transfections woundhealing wst
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