MME and EDN2

Number of citations of the paper that reports this interaction (PMID 2201681)
32

Data Source:
HPRD (in vitro)

		MME	EDN2
Gene Name		membrane metallo-endopeptidase	endothelin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Integral Component Of Membrane Axon Dendrite Neuron Projection Terminus Synapse Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Exopeptidase Activity Zinc Ion Binding Peptide Binding	Hormone Activity
	Biological Process	Kidney Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Sensory Perception Of Pain Cellular Protein Metabolic Process Creatinine Metabolic Process Beta-amyloid Metabolic Process Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence	Prostaglandin Biosynthetic Process Temperature Homeostasis Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Calcium-mediated Signaling Neutrophil Chemotaxis Macrophage Activation Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Energy Homeostasis
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Candoxatril N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1\'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 SHC1 VIP	3 interactors: CMA1 KEL MME
Entrez ID		4311	1907
HPRD ID		00392	07173
Ensembl ID		ENSG00000196549	ENSG00000127129
Uniprot IDs		P08473	P20800
PDB IDs		1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Vasodilation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Vasodilation Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Response To Stimulus Response To Hormone Positive Regulation Of Heart Contraction Cell Activation Positive Regulation Of Metabolic Process Regulation Of CAMP Metabolic Process Response To Peptide Hormone Artery Smooth Muscle Contraction Response To Peptide Regulation Of Kinase Activity Tonic Smooth Muscle Contraction Positive Regulation Of Protein Metabolic Process Response To Insulin Cellular Chemical Homeostasis Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Second-messenger-mediated Signaling Blood Circulation Response To External Stimulus Intracellular Signal Transduction Response To Stimulus Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of Vasoconstriction Positive Regulation Of Cellular Metabolic Process Vascular Smooth Muscle Contraction Histamine Secretion Negative Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Homeostasis Regulation Of Heart Rate Cellular Metal Ion Homeostasis Response To Abiotic Stimulus Phosphate-containing Compound Metabolic Process Histamine Transport Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Multicellular Organismal Development	Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Blood Circulation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Peptide Hormone Processing Regulation Of Systemic Arterial Blood Pressure Peptide Metabolic Process Interleukin-1 Beta Biosynthetic Process Regulation Of Blood Pressure Hormone Metabolic Process Proteolysis Protein Processing Cellular Amide Metabolic Process Cellular Response To UV-A Regulation Of Hormone Levels Creatinine Metabolic Process Cellular Magnesium Ion Homeostasis Response To UV-A Regulation Of Axon Diameter Cellular Response To UV-B Regulation Of Cell Projection Size Cellular Chemical Homeostasis Interleukin-1 Beta Production Negative Regulation Of Potassium Ion Transmembrane Transport Magnesium Ion Homeostasis Response To UV-B Replicative Senescence Organ Development Beta-amyloid Metabolic Process Cellular Homeostasis Negative Regulation Of Potassium Ion Transport Skeletal Muscle Fiber Development Cytokine Biosynthetic Process Myotube Cell Development Cytokine Metabolic Process Chemical Homeostasis Vasoconstriction Regulation Of Potassium Ion Transmembrane Transport System Development Negative Regulation Of Ion Transmembrane Transport Muscle Fiber Development Negative Regulation Of Transmembrane Transport Myotube Differentiation Cellular Response To UV Regulation Of Potassium Ion Transport Cellular Response To Glucose Stimulus Multicellular Organismal Development Anatomical Structure Development Cell Aging
Tagcloud ?		adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod	albino ameliorates bright damaging dawley functioning glial gs inos lif light lux macroglial maintaining muller neuroprotective nm photoreceptors preconditioning pretreatment proper qpcr ranging red retina retinal s100beta sprague vimentin
Tagcloud (Difference) ?		adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod	albino ameliorates bright damaging dawley functioning glial gs inos lif light lux macroglial maintaining muller neuroprotective nm photoreceptors preconditioning pretreatment proper qpcr ranging red retina retinal s100beta sprague vimentin
Tagcloud (Intersection) ?