FOXO4 and FOXG1

Number of citations of the paper that reports this interaction (PMID 15084259)
207

Data Source:
HPRD (in vivo)

		FOXO4	FOXG1
Gene Name		forkhead box O4	forkhead box G1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enzyme Binding Sequence-specific DNA Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Angiogenesis Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Stem Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of G0 To G1 Transition	Transcription, DNA-templated Brain Development Aging Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS			Longevity ( 20834067) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		14 interactors: AKT1 AKT2 CREBBP CTNNB1 ESR1 FOXG1 NLK PIN1 REL SFN SMAD3 SMAD4 XPO1 YWHAZ	16 interactors: APOE EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 TLE1 TLE3
Entrez ID		4303	2290
HPRD ID		02070	01283
Ensembl ID		ENSG00000184481	ENSG00000176165
Uniprot IDs		P98177	P55316
PDB IDs		1E17 3L2C
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Regulation Of Protein Localization Epithelial Cell Differentiation Regulation Of Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Signal Transduction Regulation Of Establishment Of Protein Localization Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Organelle Organization Signaling Cell Communication Response To Organic Substance Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Gene Expression Gland Development Negative Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cytokine Production Regulation Of Cell Cycle Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Cell Death Cellular Response To Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Epithelium Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Signaling Positive Regulation Of Transport	Cellular Response To Growth Factor Stimulus Response To Growth Factor Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Cellular Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Macromolecule Biosynthetic Process Response To Transforming Growth Factor Beta Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Primary MiRNA Processing Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Differentiation Mesonephros Development Organ Development Mesoderm Development Anatomical Structure Development Cardiovascular System Development
Tagcloud ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo1 foxo3a harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing ubr2 wasting	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo1 foxo3a harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing ubr2 wasting	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Intersection) ?