MLH1 and PMS2

Number of citations of the paper that reports this interaction (PMID 10037723)
30

Data Source:
HPRD (in vitro, two hybrid)

		MLH1	PMS2
Gene Name		mutL homolog 1	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton MutLalpha Complex
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	DNA Repair Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	3 interactors: EXO1 MLH1 PCNA
Entrez ID		4292	5395
HPRD ID		00390	02598
Ensembl ID		ENSG00000076242	ENSG00000122512
Uniprot IDs		P40692 Q59EG3	P54278
PDB IDs		3NA3 3RBN	1EA6 1H7S 1H7U
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation DNA Recombination Isotype Switching Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response DNA Repair Immunoglobulin Production Cellular Response To DNA Damage Stimulus DNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Leukocyte Activation Involved In Immune Response B Cell Activation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Cell Cycle Meiotic Cell Cycle Negative Regulation Of Mitotic Recombination Leading Strand Elongation Cellular Response To Stress Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Lymphocyte Activation Spindle Midzone Assembly Aromatic Compound Catabolic Process Leukocyte Activation Translesion Synthesis Resolution Of Meiotic Recombination Intermediates Nucleotide-excision Repair, DNA Gap Filling Cell Activation Telomere Maintenance Via Semi-conservative Replication RNA Metabolic Process Immune System Development Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nuclear DNA Replication Telomere Maintenance Via Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Response To Stress
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	additive agents alkylating alters biopsies brafv600e driving fotemustine genotoxic initially kill killed melanoma metastatic mgmt mlh1 msh2 msh6 necessitates question raf reasonable refractory requirement sequential subgroup synergistically temozolomide vemurafenib
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	additive agents alkylating alters biopsies brafv600e driving fotemustine genotoxic initially kill killed melanoma metastatic mgmt msh2 msh6 necessitates question raf reasonable refractory requirement sequential subgroup synergistically temozolomide vemurafenib
Tagcloud (Intersection) ?		mlh1