ATXN3 and ASIC1

Number of citations of the paper that reports this interaction (PMID 15952105)
1

Data Source:
BioGRID (two hybrid)

		ATXN3	ASIC1
Gene Name		ataxin 3	acid sensing (proton gated) ion channel 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	Protein Binding Ligand-gated Sodium Channel Activity Acid-sensing Ion Channel Activity
	Biological Process	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein	Transport Sodium Ion Transport Calcium Ion Transport Signal Transduction Response To PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sensory Perception Of Sour Taste Transmembrane Transport Protein Homotrimerization Cellular Response To PH
Pathways			Ion channel transport Stimuli-sensing channels
Drugs			Diclofenac Amiloride
Diseases
GWAS		Height ( 18391950 18391951) Orofacial clefts ( 22419666)
Protein-Protein Interactions		43 interactors: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 C16orf70 CASP1 CDKN1A CSNK2B DNM2 EWSR1 GSK3B HDAC6 KAT2B MKNK1 NCOR1 PARK2 PICK1 PJA1 PSMD7 RAD23A RAD23B RFFL RPS6KA1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP	5 interactors: ASIC2 ATXN3 PICK1 PRKACA STOM
Entrez ID		4287	41
HPRD ID		06131	04182
Ensembl ID		ENSG00000066427	ENSG00000110881
Uniprot IDs		P54252	A8K1U5 P78348
PDB IDs		1YZB 2AGA 2DOS 2JRI 2KLZ
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Proteolysis Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Macromolecule Catabolic Process Protein Ubiquitination Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Regulation Of Catalytic Activity Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Metabolic Process Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Abiotic Stimulus Cellular Response To Stress Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cell Death Catabolic Process Response To Growth Factor Protein Metabolic Process Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process	Regulation Of Cation Channel Activity Synaptic Transmission Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell-cell Signaling Response To Abiotic Stimulus Regulation Of Ion Transmembrane Transport Phototransduction Regulation Of Blood Coagulation Regulation Of Ion Transport Detection Of Light Stimulus Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Acid-sensing Ion Channel Activity Positive Regulation Of Transport Regulation Of Wound Healing Cell Maturation Histone H3-T6 Phosphorylation Nervous System Development Detection Of Abiotic Stimulus Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning DNA Methylation Involved In Embryo Development Cellular Response To Acidic PH Regulation Of Synaptic Transmission Positive Regulation Of Cellular Component Biogenesis Desmosome Assembly Monoubiquitinated Protein Deubiquitination Dendritic Spine Maintenance Negative Regulation Of Glial Cell Apoptotic Process Response To Light Stimulus Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Neuronal Ion Channel Clustering Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Response To Parathyroid Hormone Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Protein Export From Nucleus Misfolded Or Incompletely Synthesized Protein Catabolic Process Negative Regulation Of Actin Nucleation Cell Communication By Electrical Coupling Cellular Response To Misfolded Protein Cellular Response To PH
Tagcloud ?		14q32 amplifies ataxia atm atnx3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless pnkp polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable	amiloride asic2a asic3 asics blocker currents cyclooxygenase defense elusive exact existed existence glia homomeric lipopolysaccharide meanwhile microglia microglial neuroinflammatory nonspecific participate pctx1 qpcr scavenger scrape sensing transcriptase
Tagcloud (Difference) ?		14q32 amplifies ataxia atm atnx3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless pnkp polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable	amiloride asic2a asic3 asics blocker currents cyclooxygenase defense elusive exact existed existence glia homomeric lipopolysaccharide meanwhile microglia microglial neuroinflammatory nonspecific participate pctx1 qpcr scavenger scrape sensing transcriptase
Tagcloud (Intersection) ?