MGMT and CSNK2A2

Number of citations of the paper that reports this interaction (PMID 10667577)
6

Data Source:
BioGRID (enzymatic study)

		MGMT	CSNK2A2
Gene Name		O-6-methylguanine-DNA methyltransferase	casein kinase 2, alpha prime polypeptide
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Nucleus Cytosol PcG Protein Complex
	Molecular Function	DNA Binding Damaged DNA Binding Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Calcium Ion Binding Methyltransferase Activity DNA-methyltransferase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding
	Biological Process	DNA Ligation DNA Repair DNA Methylation DNA Dealkylation Involved In DNA Repair Response To Toxic Substance Cellular Response To Oxidative Stress Response To Drug Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of DNA Repair Response To Folic Acid Negative Regulation Of Cell Death Mammary Gland Epithelial Cell Differentiation Cellular Response To Organic Cyclic Compound Cellular Response To Ionizing Radiation	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Axon Guidance Wnt Signaling Pathway Mitotic Spindle Checkpoint
Pathways		DNA Damage Reversal	Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs		L-Cysteine S-Methylcysteine Benzylcysteine
Diseases
GWAS		Response to temozolomide ( 23047291) Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		8 interactors: CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 PRKACA PRKCA UBA1	92 interactors: ABCA1 ACACA ADH1A AQP4 ARR3 ARRB2 ASL ATF1 ATF2 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L HDAC1 HDAC2 HDAC6 HIST1H1C HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 JUN KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL P4HB PAK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		4255	1459
HPRD ID		01135	00279
Ensembl ID			ENSG00000070770
Uniprot IDs		B4DEE8 P16455	P19784
PDB IDs		1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH	3E3B 3OFM 3U87
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis N-terminal Peptidyl-lysine Acetylation Histone H3-T6 Phosphorylation Chromatin Modification Positive Regulation Of Phospholipase C Activity Anatomical Structure Morphogenesis Mitotic Cell Cycle Process Chromatin Organization Mitotic Cell Cycle Positive Regulation Of Phospholipase Activity Rhythmic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Cycle Histone Modification Cell Surface Receptor Signaling Pathway Apoptotic Process Regulation Of Mitotic Cell Cycle N-terminal Protein Amino Acid Acetylation Negative Regulation Of Glucose Import Cellular Protein Modification Process Positive Regulation Of Macrophage Differentiation Programmed Cell Death Chromosome Organization Desmosome Organization Cell Cycle Process Cell Death Death Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemotaxis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Proteasomal Protein Catabolic Process Regulation Of Rhodopsin Mediated Signaling Pathway N-terminal Protein Amino Acid Modification Cellular Response To Stimulus	Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Abiotic Stimulus Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Stimulus Regulation Of Gene Expression Developmental Process Innate Immune Response Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune System Process Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus Immune Response-regulating Signaling Pathway Cellular Response To Stress Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Response To Organic Cyclic Compound Regulation Of Signaling Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process Gene Expression Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Immune Response Regulation Of Phosphorylation Cell Differentiation Negative Regulation Of Signal Transduction Anatomical Structure Development Nitrogen Compound Metabolic Process Multicellular Organismal Development Defense Response Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression
Tagcloud ?		bcnu bis cenu chloroethyl chloroethylnitrosourea complementing confirm correlations cytotoxicity deficiency ercc2 excision innate lines methylguanine methyltransferase modifying nitrosourea nucleotide o6 poor r repair resistance rich rodent sensitivity uv xpd	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		bcnu bis cenu chloroethyl chloroethylnitrosourea complementing confirm correlations cytotoxicity deficiency ercc2 excision innate lines methylguanine methyltransferase modifying nitrosourea nucleotide o6 poor r repair resistance rich sensitivity uv xpd	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase segment somatic subunit subunits synteny theileriosis
Tagcloud (Intersection) ?		rodent