METTL1 and WDR4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo, two hybrid)

		METTL1	WDR4
Gene Name		methyltransferase like 1	WD repeat domain 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm TRNA Methyltransferase Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	TRNA Binding Protein Binding TRNA (guanine-N7-)-methyltransferase Activity	Protein Binding TRNA (guanine-N7-)-methyltransferase Activity
	Biological Process	TRNA Modification TRNA Methylation RNA (guanine-N7)-methylation	TRNA Modification TRNA Methylation RNA (guanine-N7)-methylation
Pathways
Drugs
Diseases
GWAS		Multiple sclerosis ( 19525955)
Protein-Protein Interactions		3 interactors: AKT1 RPS6KA1 WDR4	5 interactors: FAM118A METTL1 RABGGTB TERF1 TERF2
Entrez ID		4234	10785
HPRD ID		06834	09330
Ensembl ID		ENSG00000037897	ENSG00000160193
Uniprot IDs		Q9UBP6	P57081
PDB IDs		3CKK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Growth Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Hepatic Stellate Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Growth Neurotrophin Signaling Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Translation Negative Regulation Of Peptidase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Cell Activation Regulation Of Cell Growth Negative Regulation Of Proteolysis RNA (guanine-N7)-methylation Response To UV-A Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Activation-induced Cell Death Of T Cells Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Posttranscriptional Regulation Of Gene Expression Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Negative Regulation Of Fatty Acid Oxidation Positive Regulation Of Glycogen Biosynthetic Process Nitric Oxide Biosynthetic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Size Response To Growth Factor Regulation Of Translation In Response To Stress Regulation Of Growth Negative Regulation Of Release Of Cytochrome C From Mitochondria Spongiotrophoblast Layer Development T Cell Apoptotic Process Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Replicative Cell Aging Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Replication Cell Aging Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Regulation Of Chromosome Organization RNA (guanine-N7)-methylation Protection From Non-homologous End Joining At Telomere Telomere Capping DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Protein Geranylgeranylation Aging Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Positive Regulation Of Organelle Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Cell Cycle Positive Regulation Of Microtubule Polymerization Regulation Of Cell Cycle Process Regulation Of Telomerase Activity Protein Prenylation Chromatin Modification TRNA Methylation Negative Regulation Of DNA Biosynthetic Process Regulation Of Microtubule Polymerization Protein Localization To Chromosome Cellular Senescence Chromatin Organization 7-methylguanosine RNA Capping Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Regulation Of DNA Biosynthetic Process Spindle Checkpoint
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