MEOX2 and SMAD3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MEOX2	SMAD3
Gene Name		mesenchyme homeobox 2	SMAD family member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Speck	Nuclear Chromatin Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Plasma Membrane Receptor Complex SMAD Protein Complex SMAD2-SMAD3 Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding Protein Binding Transcription Factor Activity RNA Polymerase II Activating Transcription Factor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Collagen Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Phosphatase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Enhancer Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Co-SMAD Binding R-SMAD Binding
	Biological Process	Angiogenesis Somite Specification Transcription, DNA-templated Multicellular Organismal Development Skeletal Muscle Tissue Development Blood Circulation Positive Regulation Of Transcription From RNA Polymerase II Promoter Palate Development Limb Development Neuron Death	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Somitogenesis Liver Development Negative Regulation Of Protein Phosphorylation Heart Looping Osteoblast Development Immune System Development Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Endoderm Development Embryonic Pattern Specification Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Evasion Or Tolerance Of Host Defenses By Virus Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Primary MiRNA Processing Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Transforming Growth Factor Beta3 Production Activin Receptor Signaling Pathway Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Catenin Import Into Nucleus Intracellular Signal Transduction Nodal Signaling Pathway Wound Healing T Cell Activation Negative Regulation Of Protein Catabolic Process Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Immune Response Protein Stabilization Positive Regulation Of Positive Chemotaxis Regulation Of Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Pericardium Development Transdifferentiation SMAD Protein Signal Transduction Negative Regulation Of Wound Healing Lens Fiber Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly
Pathways			Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494)	Asthma ( 20860503) Corneal structure ( 23291589) Coronary heart disease ( 17634449) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		207 interactors: ADAMTS12 AGPAT1 AHCYL1 AHSA2 ANP32B ARHGEF7 ARNT2 ATG5 ATXN1L BCL2L15 C19orf66 C1orf109 CARD9 CASP14 CCDC103 CCNC CDH9 CEP57L1 CHIC2 CHRD CIAPIN1 CIB3 CNTNAP2 COX1 CPNE6 CPSF4 CRCT1 CSDC2 CSF2 CTNNBL1 CXXC1 DGCR6 DGCR8 DOCK8 DYNLL2 EDF1 EFEMP2 EFNA3 EIF1AD EIF5A EPM2AIP1 ESR2 ESRRG FAM13C FAM3A FAM74A4 FBF1 FOXR1 FUCA2 FUT11 GABRB3 GAGE1 GLO1 GMCL1P1 GMPR2 GNG11 GOLGA8DP GOLGA8EP GOLGA8F GPATCH2L GPSM3 HAT1 HDHD2 HEXIM2 HGF HLA-A HNRNPD HP1BP3 HSPA2 HTR1E IGF2BP3 IGFN1 INPP1 IP6K2 ITM2A KAT5 KIZ KLC4 KLHL38 KRT80 KRT86 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KTN1 LAMTOR5 LCE1B LCE2A LCE4A LOC153684 LSM2 MAGED1 MAPKBP1 MKRN3 MLLT6 MMP3 MORN3 MRFAP1L1 MSI2 MT1DP MTMR10 MUM1 MVP MYBPC1 NAA10 NALCN NCALD NCK2 ND1 NLGN3 NTF3 OIT3 OSGIN1 P4HA3 PACSIN2 PAGE2 PARK2 PARVG PAX1 PAX3 PCDH9 PCSK5 PGBD1 PIN1 PKIG POM121C PRKAB2 PRR19 PSMB10 PSMC1 PSMD14 PTGER3 RARB RCHY1 RECK RHOJ RMND5A RND2 RPL15 RUNX1T1 SAMM50 SCNM1 SEPP1 SET SIRPB1 SLC48A1 SMAD3 SMARCE1 SPATA1 SPP1 SPRY1 SPRY2 SSX3 STK16 STX11 STX16 SYT17 TBCEL TBX6 TCEA2 TCL6 TCTEX1D1 TDO2 TGFB1 TICAM2 TMEM100 TP53BP1 TRAF6 TRIM41 TRIM42 TTC25 TTC39B TTC9C TULP2 TXLNA UBE3A UBL4A UBL4B UNC45A USE1 VEZF1 VIP WFDC9 XRCC2 ZBED4 ZMAT2 ZNF124 ZNF329 ZNF404 ZNF417 ZNF483 ZNF564 ZNF572 ZNF587 ZNF695	268 interactors: AATF ACTB AES AKT1 ANAPC10 ANK3 APMAP APOB APP AR ARHGEF6 ATF2 ATF3 AXIN1 AXIN2 BLZF1 BPTF BRCA1 BRCA2 BTRC C10orf54 CAMK2G CCDC33 CDC16 CDC25A CDC27 CDK2 CDK4 CDK8 CDK9 CEBPA CEBPB CEBPD CFDP1 CFH CFLAR CHRD CLASRP CORO1A CPSF7 CPTP CREBBP CSH2 CSNK1D CSNK1G2 CTCF CTNNB1 CUL1 CXXC5 CYP11A1 DAB2 DACH1 DDX5 DEDD DNAJB4 DVL1 E2F4 E2F5 EBI3 EID2 EIF4ENIF1 EP300 EPAS1 EPB41 ERBB2IP ESR1 ESR2 ETS1 FBLN1 FHL2 FHL3 FLI1 FLNA FOS FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 GGA1 GIT2 GLI3 GMEB1 GSC GSK3B GTF2IRD1 HDAC1 HDAC4 HDAC5 HEY1 HEYL HGS HIPK2 HIVEP1 HMGA2 HNF4A HNRNPK HOXC11 HP HSPA4 IL37 ISL1 ITCH JPH3 JUN JUNB JUND KANSL1 KAT2B KDM2A KMT2B KPNB1 KRT10 KRT2 LBP LCK LEF1 LMNA MAGI2 MAP3K7 MAPK1 MAPK14 MAPK8 MAPK9 MAX MBD1 MCM3AP MDM4 MECOM MED15 MEN1 MEOX2 MTF2 MYC MYD88 MYO5B MYOCD MYOD1 NCOA6 NEDD4 NEDD4L NEDD9 NF1 NFYC NOTCH1 NOTCH4 NR3C1 NR4A1 NUP153 NUP214 OTUB1 PAEP PAPPA PARD3 PARD3B PARP4 PAX8 PCDH1 PCK2 PEX6 PHC2 PIAS2 PIAS3 PIAS4 PIK3CA PIN1 PLAG1 PLAGL1 PLG PML PPM1A PPP1R12C PPP2R1A PRDM4 PRKAR1B PRKAR2A PROX1 PRTN3 PSMD11 RAB38 RANBP9 RARG RASD2 RASL12 RBL1 RBX1 RCVRN RELA RIOK2 RIT1 RNF111 RNF31 RPA1 RPLP0 RRAS2 RUNX2 RUNX3 S100A4 SAP130 SERTAD1 SETD2 SF3A1 SF3B2 SIN3A SKI SKIL SKOR2 SMAD1 SMAD2 SMAD4 SMAD9 SMURF1 SMURF2 SNRNP70 SNW1 SP1 SPTBN1 SQSTM1 SREBF2 SRY SS18L1 ST6GALNAC2 STRAP STUB1 SVEP1 TANK TDP2 TEKT4 TF TFE3 TGFBR1 TGFBR2 TGIF1 TGIF2 TGM2 TLR4 TMED1 TOB1 TP53 TP73 TPM3 TSC2 TSC22D4 UBQLN4 UCHL5 USP15 USP7 VDR VIM WEE1 WWP1 WWP2 XRCC6 YBX1 YY1 ZBTB16 ZBTB3 ZC3H12A ZCCHC14 ZDHHC4 ZEB1 ZEB2 ZFYVE9 ZMYM2 ZMYND11 ZNF329 ZNF8 ZNF83
Entrez ID		4223	4088
HPRD ID		02760	04380
Ensembl ID		ENSG00000106511	ENSG00000166949
Uniprot IDs		P50222	P84022 Q9P0T0
PDB IDs			1MHD 1MJS 1MK2 1OZJ 1U7F 2LAJ 2LB2
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Death Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Epithelium Development Positive Regulation Of Gene Expression Developmental Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Cell Death Regulation Of RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Death Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of DNA Binding RNA Metabolic Process System Development Regulation Of Protein Ubiquitination Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Binding Myeloid Dendritic Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Ubiquitination Myeloid Dendritic Cell Activation	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Response To Growth Factor Cellular Response To Organic Substance RNA Metabolic Process Gene Expression Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stimulus Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Organ Development Signal Transduction Developmental Process
Tagcloud ?		activates angiogenic biphasic colocalization colocalizes constructs depend ec ecs homeobox homeodomain homeoprotein hypothesize ikappabbeta immunofluorescence implicate ingrowth modulate modulates normally p65 proangiogenic promoters rela represses secrete stimulates transduced vessels	adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad4 smads squelching tgf transactivation transduce
Tagcloud (Difference) ?		activates angiogenic biphasic colocalization colocalizes depend ec ecs homeobox homeodomain homeoprotein hypothesize ikappabbeta immunofluorescence implicate ingrowth modulate normally p65 proangiogenic promoters rela represses secrete stimulates transduced vessels	adenoviral autoinhibitory cdk coactivators competing conformational creb define e1a effector facilitating fragment interacting oncoprotein p15 p300 participate possibility potentiates removes smad4 smads squelching tgf transactivation transduce
Tagcloud (Intersection) ?		constructs modulates