MAP3K4 and GADD45B

Number of citations of the paper that reports this interaction (PMID 9827804)
140

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MAP3K4	GADD45B
Gene Name		mitogen-activated protein kinase kinase kinase 4	growth arrest and DNA-damage-inducible, beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Placenta Development Protein Phosphorylation Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade	Activation Of MAPKKK Activity Activation Of MAPKK Activity Negative Regulation Of Protein Kinase Activity Apoptotic Process Response To Stress Multicellular Organismal Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade
Pathways
Drugs
Diseases
GWAS		Aging ( 22773346)
Protein-Protein Interactions		26 interactors: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MAPK8 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	13 interactors: CCNB1 CDK1 CDKN1A ESR1 GADD45G GADD45GIP1 MAP2K7 MAP3K4 MAP3K5 PCNA PPARA PPARD PPARG
Entrez ID		4216	4616
HPRD ID		03886	05382
Ensembl ID		ENSG00000085511	ENSG00000099860
Uniprot IDs		F5H538 J3KNB8 Q9P1M2 Q9Y6R4	O75293
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Transferase Activity Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity MAPK Cascade Regulation Of Catalytic Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Signal Transduction By Phosphorylation Apoptotic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Programmed Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Activation Of MAPKK Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Lipid Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Heart Development Positive Regulation Of Protein Modification Process Regulation Of Fibroblast Proliferation Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Apoptotic Process Cellular Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Hormone-mediated Signaling Pathway Tissue Development Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Stress Response To Organic Substance Activation Of MAPK Activity Cellular Response To Organic Substance G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Cyclic Compound Positive Regulation Of Signal Transduction Regulation Of JNK Cascade Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Lipid Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deleterious deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe ovarian palb2 pathogenic rare somatic truncation truncations variants	abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing
Tagcloud (Difference) ?		analyse annotation bioinformatics brca1 brca2 cdkn2b deleterious deletions enrichment exome fanconi germline heterozygosity identifies integrated landscape missense mll mll3 nf1 observe ovarian palb2 pathogenic rare somatic truncation truncations variants	abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing
Tagcloud (Intersection) ?