MAP3K3 and CDC37

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MAP3K3	CDC37
Gene Name		mitogen-activated protein kinase kinase kinase 3	cell division cycle 37
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Cytoplasm Cytosol Ruffle Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding Kinase Binding Heat Shock Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Kinase B Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS		Height ( 21998595 22021425 18391951)	Multiple sclerosis ( 21833088)
Protein-Protein Interactions		44 interactors: BIRC2 BRCA1 CDC37 COPS5 GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K2 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 SQSTM1 TOM1L1 TRAF6 TRAF7 UBC VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	72 interactors: A2M APOE APP AR BTBD10 C19orf44 CC2D1A CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CYP2C9 DCTN1 DEAF1 ECSIT EIF2AK1 ELAVL3 EXOSC1 FBXL12 FBXW4 GCDH GCH1 HSP90AA1 IFIT3 IFIT5 IKBKB IKBKE IKBKG IMMT LONP1 LOXL4 LUC7L2 MAP3K14 MAP3K3 MGEA5 MTOR MZT2B NCOA5 NOS3 NR2C2 PPHLN1 PRAM1 PRDX2 PRMT1 PSME1 RAD23A RNF32 RPS15A SAFB SNX5 SPTBN4 SQSTM1 SRC STAMBPL1 STIP1 STK11 TBK1 UBE2I ZNF205 ZNF235 ZNF266 ZNF667
Entrez ID		4215	11140
HPRD ID		03965	05456
Ensembl ID		ENSG00000198909	ENSG00000105401
Uniprot IDs		J3KRN4 J3QRB6 Q99759	Q16543
PDB IDs		2C60 2JRH 2O2V 2PPH	1US7 2K5B 2W0G
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Death Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Cell Death Activation Of MAPK Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response JNK Cascade Signaling Response To Stress Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of MAP Kinase Activity Regulation Of MAP Kinase Activity	Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Cellular Metabolic Process Response To External Stimulus Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mitotic Cell Cycle Phase Transition Response To Virus Cell Cycle Phase Transition Catabolic Process Regulation Of Catalytic Activity Intracellular Receptor Signaling Pathway Cell Cycle Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cell Cycle Process Regulation Of Signal Transduction Protein Catabolic Process Mitotic Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signaling Toll-like Receptor 3 Signaling Pathway Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus
Tagcloud ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 stabilization striking tatgggga
Tagcloud (Difference) ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 stabilization striking tatgggga
Tagcloud (Intersection) ?