MEF2C and HDAC9

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid, two hybrid)

		MEF2C	HDAC9
Gene Name		myocyte enhancer factor 2C	histone deacetylase 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle Protein Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding AT DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Activating Transcription Factor Binding MiRNA Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Blood Vessel Development Osteoblast Differentiation Neuron Migration B Cell Homeostasis Heart Looping Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Toll-like Receptor Signaling Pathway Germinal Center Formation Regulation Of Germinal Center Formation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Ischemia Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Sinoatrial Valve Morphogenesis Cardiac Ventricle Formation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Nervous System Development Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Muscle Cell Fate Determination Learning Or Memory Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Alkaline Phosphatase Activity Neural Crest Cell Differentiation Cardiac Muscle Hypertrophy In Response To Stress Myotube Differentiation Neuron Differentiation Platelet Formation Monocyte Differentiation Negative Regulation Of Ossification Melanocyte Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of B Cell Proliferation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Drug Cellular Response To Trichostatin A Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway B Cell Proliferation Muscle Cell Differentiation Positive Regulation Of MAP Kinase Activity Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Regulation Of Megakaryocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Skeletal Muscle Tissue Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Embryonic Viscerocranium Morphogenesis Negative Regulation Of Epithelial Cell Proliferation B Cell Receptor Signaling Pathway Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Ventricular Cardiac Muscle Cell Differentiation Palate Development Regulation Of Synaptic Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Sarcomere Organization Cartilage Morphogenesis Regulation Of Dendritic Spine Development Renal Tubule Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Macrophage Apoptotic Process Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Behavioral Fear Response Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Positive Regulation Of Skeletal Muscle Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Inflammatory Response Notch Signaling Pathway Heart Development Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Peptidyl-lysine Deacetylation B Cell Activation Negative Regulation Of Transcription, DNA-templated Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Mitochondrial biogenesis Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transcriptional activation of mitochondrial biogenesis Nuclear Events (kinase and transcription factor activation)	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs			Valproic Acid
Diseases
GWAS		Bone mineral density ( 21533022 23572186 22504420) Bone mineral density (hip) ( 19801982) Height ( 20881960) Mean platelet volume ( 22139419) Platelet counts ( 22139419) Retinal arteriolar caliber ( 23776548) Retinal vascular caliber ( 21060863) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Tonometry ( 17903302)	Male-pattern baldness ( 22693459) Obesity-related traits ( 23251661) Retinopathy in non-diabetics ( 23393555) Stroke ( 22306652) Stroke (ischemic) ( 23041239) Ulcerative colitis ( 20848476)
Protein-Protein Interactions		30 interactors: ASCL1 CCNB1 CDK1 COPS5 CSNK2A1 EP300 EPAS1 GATA4 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NCOA2 NOTCH1 PLA2G12A SMAD2 SOX18 SP1 SPTBN1 SUMO1 TEAD1 TWIST2 VGLL2 VGLL4 YWHAZ	31 interactors: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 HDAC1 HDAC3 HDAC4 HIST2H3A HIST4H4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 NRIP1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SUV39H1 SYK TRIM29 USF1 YWHAZ ZBTB16
Entrez ID		4208	9734
HPRD ID		02809	05944
Ensembl ID		ENSG00000081189	ENSG00000048052
Uniprot IDs		D6R9J8 D8L7E9 Q06413	B7Z3P7 Q9UKV0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Striated Muscle Tissue Development Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Myotube Differentiation Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Skeletal Muscle Fiber Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Heart Development Nitrogen Compound Metabolic Process Cardiovascular System Development Positive Regulation Of Metabolic Process Regulation Of Striated Muscle Cell Differentiation Biosynthetic Process Organ Development System Development Striated Muscle Tissue Development Developmental Process Anatomical Structure Development Muscle Tissue Development Cell Differentiation Regulation Of Muscle Cell Differentiation Cellular Metabolic Process Muscle Structure Development Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Cell Differentiation Positive Regulation Of Striated Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Development	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor 2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Activation Of Innate Immune Response RNA Metabolic Process Regulation Of Histone Deacetylation Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Binding Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stress
Tagcloud ?		abolishes abrogates adapters assist autoregulatory bhlh carboxy cbp coactivate coactivation coactivators converting diminishes drastically fyd helix mads multimers myocyte myod myogenesis myogenic physically potentiated reinforcing searching terminals transactivation	ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Difference) ?		abolishes abrogates adapters assist autoregulatory bhlh carboxy cbp coactivate coactivation coactivators converting diminishes drastically fyd helix mads multimers myocyte myod myogenesis myogenic physically potentiated reinforcing searching terminals transactivation	ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Intersection) ?