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MCM7 and ORC3
Number of citations of the paper that reports this interaction (PMID
12614612
)
16
Data Source:
HPRD
(two hybrid)
MCM7
ORC3
Gene Name
minichromosome maintenance complex component 7
origin recognition complex, subunit 3
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Chromatin
Nucleoplasm
Cytoplasm
Cytosol
Membrane
MCM Complex
Origin Recognition Complex
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Molecular Function
DNA Binding
Single-stranded DNA Binding
ATP-dependent DNA Helicase Activity
Protein Binding
ATP Binding
DNA Replication Origin Binding
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Cellular Response To DNA Damage Stimulus
Cell Proliferation
Regulation Of Phosphorylation
Response To Drug
Cellular Response To Epidermal Growth Factor Stimulus
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
Neural Precursor Cell Proliferation
Pathways
Synthesis of DNA
G2/M Checkpoints
Activation of the pre-replicative complex
DNA Replication Pre-Initiation
M/G1 Transition
Regulation of DNA replication
Activation of the pre-replicative complex
Orc1 removal from chromatin
S Phase
DNA strand elongation
Cell Cycle, Mitotic
Assembly of the pre-replicative complex
Orc1 removal from chromatin
G1/S Transition
Activation of ATR in response to replication stress
Cell Cycle Checkpoints
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
Unwinding of DNA
G2/M Checkpoints
Activation of the pre-replicative complex
Activation of the pre-replicative complex
Orc1 removal from chromatin
Assembly of the pre-replicative complex
Activation of ATR in response to replication stress
G1/S Transition
Assembly of the ORC complex at the origin of replication
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
E2F mediated regulation of DNA replication
Synthesis of DNA
DNA Replication Pre-Initiation
Regulation of DNA replication
M/G1 Transition
S Phase
CDC6 association with the ORC:origin complex
Cell Cycle, Mitotic
Orc1 removal from chromatin
E2F-enabled inhibition of pre-replication complex formation
Cell Cycle Checkpoints
Association of licensing factors with the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
59 interactors:
AK8
APP
ASB8
C8orf34
CCDC102B
CCND1
CCNH
CDC45
CDC6
CDC7
CDK7
CDKN1B
CDT1
CRLS1
DBF4
FHL2
GOLGA2
HIF1A
HIST3H3
IKBKG
INTS6
KIFC3
MBIP
MCM10
MCM2
MCM3
MCM4
MCM5
MCM6
MCM8
MCMBP
MIPOL1
MNAT1
NAB2
NFKBIA
ORC1
ORC2
ORC3
ORC4
ORC5
ORC6
PLK1
PNMA1
RAD17
RB1
RBL1
RBL2
RBM8A
RPA1
SMC1A
SNTA1
SP2
TCEB1
TREX1
TRIM27
TRIM54
UBE3A
UBQLN1
USHBP1
18 interactors:
APP
CCNE2
CDC45
CDC6
CDK4
DBF4
HIST3H3
HIST4H4
MCM10
MCM4
MCM5
MCM7
ORC1
ORC2
ORC4
ORC5
ORC6
TERF2
Entrez ID
4176
23595
HPRD ID
01154
05398
Ensembl ID
ENSG00000166508
ENSG00000135336
Uniprot IDs
C6EMX8
P33993
Q9UBD5
PDB IDs
Enriched GO Terms of Interacting Partners
?
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Mitotic Cell Cycle
Mitotic Cell Cycle Process
DNA Replication
Cell Cycle
Cell Cycle Process
DNA-dependent DNA Replication
DNA Replication Initiation
DNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Biosynthetic Process
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Metabolic Process
Positive Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Cellular Response To DNA Damage Stimulus
Cellular Response To Stress
Chromosome Organization
Regulation Of Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Cell Cycle Checkpoint
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
DNA Replication Checkpoint
Positive Regulation Of Mitotic Cell Cycle
DNA Duplex Unwinding
DNA Geometric Change
Regulation Of Phosphorylation
Regulation Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Kinase Activity
Nucleotide-excision Repair, DNA Damage Removal
Regulation Of Phosphorus Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Cell Cycle Process
Positive Regulation Of Cell Cycle
Intracellular Receptor Signaling Pathway
Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Replication
DNA Replication Initiation
Mitotic Cell Cycle
DNA Metabolic Process
DNA-dependent DNA Replication
Mitotic Cell Cycle Process
Cell Cycle
Cell Cycle Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Strand Elongation Involved In DNA Replication
Cellular Macromolecule Biosynthetic Process
DNA Strand Elongation
Macromolecule Biosynthetic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Cellular Metabolic Process
DNA Duplex Unwinding
Biosynthetic Process
DNA Geometric Change
Chromosome Organization
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Conformation Change
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Telomere Maintenance
DNA Replication Checkpoint
DNA Unwinding Involved In DNA Replication
Regulation Of Cell Cycle
Positive Regulation Of Cell Cycle
Metabolic Process
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle G1/S Phase Transition
Organelle Organization
Regulation Of Mitotic Cell Cycle
Cell Division
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of DNA Replication
Cell Cycle Checkpoint
Tagcloud
?
aldh1a1
anxa1
bcar1
cldn1
crmp1
endpoint
folr1
foxm1
il12rb2
il7r
inconclusive
kiaa1524
lox
mta1
mtdh
ncoa3
ndrg2
nedd9
nes
overview
pbk
ppm1d
principally
prognostication
qualifying
slc7a5
sqstm1
warranted
wnt1
Tagcloud (Difference)
?
aldh1a1
anxa1
bcar1
cldn1
crmp1
endpoint
folr1
foxm1
il12rb2
il7r
inconclusive
kiaa1524
lox
mta1
mtdh
ncoa3
ndrg2
nedd9
nes
overview
pbk
ppm1d
principally
prognostication
qualifying
slc7a5
sqstm1
warranted
wnt1
Tagcloud (Intersection)
?