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MCM2 and GTF2H1
Number of citations of the paper that reports this interaction (PMID
12392551
)
11
Data Source:
HPRD
(in vitro)
MCM2
GTF2H1
Gene Name
minichromosome maintenance complex component 2
general transcription factor IIH, polypeptide 1, 62kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Cytoplasm
Microtubule Cytoskeleton
MCM Complex
Core TFIIH Complex
Nucleoplasm
Holo TFIIH Complex
Molecular Function
DNA Binding
DNA Helicase Activity
DNA Replication Origin Binding
Protein Binding
ATP Binding
Histone Binding
Metal Ion Binding
Protein Kinase Activity
Protein Binding
DNA-dependent ATPase Activity
RNA Polymerase II Carboxy-terminal Domain Kinase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Nucleosome Assembly
Cell Cycle
Cellular Response To Interleukin-4
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Nucleotide-excision Repair, DNA Damage Removal
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Phosphorylation
Gene Expression
Viral Process
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Viral Transcription
Pathways
Synthesis of DNA
G2/M Checkpoints
Activation of the pre-replicative complex
DNA Replication Pre-Initiation
M/G1 Transition
Regulation of DNA replication
Activation of the pre-replicative complex
Orc1 removal from chromatin
S Phase
DNA strand elongation
Cell Cycle, Mitotic
Assembly of the pre-replicative complex
Orc1 removal from chromatin
G1/S Transition
Activation of ATR in response to replication stress
Cell Cycle Checkpoints
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
Unwinding of DNA
RNA Polymerase II Promoter Escape
Formation of HIV-1 elongation complex containing HIV-1 Tat
Nucleotide Excision Repair
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HIV Infection
Formation of the Early Elongation Complex
Tat-mediated elongation of the HIV-1 transcript
Formation of transcription-coupled NER (TC-NER) repair complex
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
Dual incision reaction in TC-NER
NoRC negatively regulates rRNA expression
HIV Transcription Initiation
HIV Life Cycle
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II HIV Promoter Escape
HIV Transcription Elongation
Dual incision reaction in GG-NER
mRNA Capping
RNA Polymerase I Transcription
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Late Phase of HIV Life Cycle
Formation of RNA Pol II elongation complex
Global Genomic NER (GG-NER)
RNA Polymerase II Transcription Initiation And Promoter Clearance
Transcription-coupled NER (TC-NER)
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of incision complex in GG-NER
RNA Polymerase II Transcription Initiation
Transcription of the HIV genome
RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Amyloid A Levels (
21124955
)
Pancreatic cancer (
23180869
)
Protein-Protein Interactions
47 interactors:
AKAP8
APP
ATM
ATR
CCNB2
CCNC
CDC6
CDC7
CDK2
CDK4
CDK6
CDKN2A
CPSF1
CSNK2A1
DBF4
ELL
GNB5
GTF2B
GTF2H1
HIST3H3
KAT7
MCM10
MCM3
MCM4
MCM5
MCM6
MCM7
MCPH1
MOB4
MPP3
ORC1
ORC2
ORC4
ORC5
ORC6
P2RX4
PHC2
PLK1
RAD52
RPA1
RPA2
RPA3
RPS4X
TBP
TCEA2
TERF1
TERF2IP
42 interactors:
ACTN1
AR
ATF7IP
BRPF1
CCNH
CCSER2
CDK7
CTD
E2F1
ERCC2
ERCC3
ERCC4
ERCC5
ESR1
FUBP1
GTF2E1
GTF2E2
GTF2H2
GTF2H3
HNF4A
HNRNPU
HOXC11
JDP2
KIF13A
KPNA3
MCM2
MMS19
PIK3R1
PLCG1
POU2AF1
PSMC2
RAD23A
REEP5
RXRB
TNIP1
TP53
TRIOBP
TXNRD2
USHBP1
XPA
XPC
ZSCAN1
Entrez ID
4171
2965
HPRD ID
00303
01807
Ensembl ID
ENSG00000073111
ENSG00000110768
Uniprot IDs
P49736
P32780
PDB IDs
1PFJ
2DII
2RNR
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Process
DNA Replication
Mitotic Cell Cycle
Cell Cycle Process
DNA Metabolic Process
Cell Cycle
DNA-dependent DNA Replication
DNA Replication Initiation
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Biosynthetic Process
Chromosome Organization
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Cellular Metabolic Process
DNA Recombinase Assembly
Telomere Maintenance
Regulation Of Cell Cycle Process
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Positive Regulation Of Cell Cycle Process
Regulation Of Cellular Response To Heat
Positive Regulation Of Cell Cycle
Telomere Maintenance Via Telomere Lengthening
Cell Division
Cell Cycle Checkpoint
Double-strand Break Repair
Organelle Organization
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Cellular Response To DNA Damage Stimulus
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Nucleotide-excision Repair, DNA Damage Removal
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Nucleotide-excision Repair, DNA Damage Removal
Nucleotide-excision Repair
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Transcription-coupled Nucleotide-excision Repair
Viral Process
Cellular Response To DNA Damage Stimulus
Transcription From RNA Polymerase II Promoter
DNA Catabolic Process
Transcription Elongation From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription, DNA-templated
Positive Regulation Of Gene Expression
Response To UV
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA-templated Transcription, Elongation
Positive Regulation Of Cellular Biosynthetic Process
RNA Biosynthetic Process
Termination Of RNA Polymerase I Transcription
Gene Expression
Transcription Elongation From RNA Polymerase I Promoter
Nitrogen Compound Metabolic Process
DNA Repair
Transcription Initiation From RNA Polymerase I Promoter
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
7-methylguanosine MRNA Capping
Transcription From RNA Polymerase I Promoter
7-methylguanosine RNA Capping
Positive Regulation Of Viral Process
DNA Metabolic Process
RNA Metabolic Process
Cellular Response To Stress
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Viral Transcription
Regulation Of Viral Process
Nucleotide-excision Repair, DNA Incision
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Regulation Of Viral Transcription
Response To Stress
Tagcloud
?
1alpha
1beta
bcl2
carcinogenic
ccr2
cervices
e2
epithelia
hek293
hpv16
ikappabalpha
inflammation
intact
integration
isomerase
mediators
peptidyl
pin1
potentiated
prolyl
rela
sdf
ser727
squamous
stat3
stromal
supports
survivin
transformed
Tagcloud (Difference)
?
1alpha
1beta
bcl2
carcinogenic
ccr2
cervices
e2
epithelia
hek293
hpv16
ikappabalpha
inflammation
intact
integration
isomerase
mediators
peptidyl
pin1
potentiated
prolyl
rela
sdf
ser727
squamous
stat3
stromal
supports
survivin
transformed
Tagcloud (Intersection)
?