MAN2C1 and PRRC2A

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAN2C1	PRRC2A
Gene Name		mannosidase, alpha, class 2C, member 1	proline-rich coiled-coil 2A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Alpha-mannosidase Activity Zinc Ion Binding Carbohydrate Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Mannose Metabolic Process
Pathways
Drugs
Diseases
GWAS			Menopause (age at onset) ( 22267201) Schizophrenia ( 23894747)
Protein-Protein Interactions		4 interactors: BRCA1 EXOSC6 PRRC2A XRN1	27 interactors: ATN1 ATXN1 C1QBP CCR10 CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 P4HA2 PRMT2 PSMA3 QARS RBFOX1 RERE SSR3 UBAP2L
Entrez ID		4123	7916
HPRD ID		01109	00807
Ensembl ID		ENSG00000140400	ENSG00000204469
Uniprot IDs		Q9NTJ4	P48634
PDB IDs
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Histone H3-K9 Acetylation DNA Recombination Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Dosage Compensation By Inactivation Of X Chromosome Nuclear MRNA Surveillance Protein K6-linked Ubiquitination DNA Deamination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation RNA Surveillance Regulation Of Histone H3-K9 Acetylation Aromatic Compound Catabolic Process Histone MRNA Catabolic Process NcRNA Metabolic Process Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation RRNA Catabolic Process MRNA Metabolic Process Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Histone MRNA Metabolic Process Postreplication Repair Positive Regulation Of Protein Acetylation Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Gene Expression By Genetic Imprinting	Gene Expression MRNA Metabolic Process RNA Splicing RNA Metabolic Process RNA Processing MRNA Processing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cytoplasmic Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Signal Transduction In Response To DNA Damage Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nuclear Export Nuclear Import Negative Regulation Of Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading RNA Transport Negative Regulation Of Mitotic Cell Cycle Phase Transition RNA Localization Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Metabolic Process Ribonucleoprotein Complex Assembly Negative Regulation Of Signal Transduction Glutaminyl-tRNA Aminoacylation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Cellular Response To Potassium Ion Starvation Negative Regulation Of DNA Binding Negative Regulation Of Signaling Regulation Of Cell Morphogenesis Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle
Tagcloud ?		129p3 6byj acat1 adip5 adipose adpgk bbs4 crabp1 csk cyp19a1 depot depots dpp8 fatness gonadal hexa il18 intercross linkage lipc lod lsm16 mpi1 neil1 qtl retroperitoneal rs30280752 summed thsd4
Tagcloud (Difference) ?		129p3 6byj acat1 adip5 adipose adpgk bbs4 crabp1 csk cyp19a1 depot depots dpp8 fatness gonadal hexa il18 intercross linkage lipc lod lsm16 mpi1 neil1 qtl retroperitoneal rs30280752 summed thsd4
Tagcloud (Intersection) ?