SMAD4 and DVL1

Number of citations of the paper that reports this interaction (PMID 12650946)
10

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SMAD4	DVL1
Gene Name		SMAD family member 4	dishevelled segment polarity protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome Cytosol Activin Responsive Factor Complex SMAD Protein Complex	Cytoplasm Cytosol Microtubule Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Synapse
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Proximal Region Sequence-specific DNA Binding Protein Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Collagen Binding Transforming Growth Factor Beta Receptor, Common-partner Cytoplasmic Mediator Activity Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding I-SMAD Binding R-SMAD Binding	Molecular_function Frizzled Binding Protein Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Rac GTPase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Gastrulation With Mouth Forming Second Atrioventricular Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Septum Development Brainstem Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Axon Guidance Endoderm Development Mesoderm Development Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Somite Rostral/caudal Axis Specification Regulation Of Transforming Growth Factor Beta2 Production Somatic Stem Cell Maintenance Intracellular Signal Transduction Atrioventricular Canal Development Endothelial Cell Activation Negative Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Neuron Fate Commitment Sebaceous Gland Development Formation Of Anatomical Boundary Regulation Of Binding Regulation Of Hair Follicle Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Negative Regulation Of Cell Death Endocardial Cell Differentiation Response To Transforming Growth Factor Beta Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis	Regulation Of Neurotransmitter Levels Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Wnt Signaling Pathway Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Receptor Clustering Positive Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Immune response to anthrax vaccine ( 22658931)
Protein-Protein Interactions		174 interactors: ACVR1B AKT1 AP2B1 APBB2 AR ARFRP1 ARL5B ATF2 ATF7IP BRCA1 BTRC CAMK2G CD59 CEBPA CEBPB CEBPD CHEK1 CITED1 CNKSR1 COPS5 CREBBP CSH1 CSH2 CTCF CTNNB1 CYFIP2 DACH1 DCP1A DCP1B DLX1 DNAJB2 DVL1 ECSIT EEF1A1 EID2 EIF2AK4 EP300 ERBB2IP ESR1 ESR2 EWSR1 FBLN1 FBXO30 FBXO34 FHL2 FHL3 FN1 FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 FSTL3 GATA2 GLI3 GPNMB HDGF HDLBP HMG20A HNF4A HOXA9 HOXC8 ITK JUN JUNB JUND LEF1 LMO4 MAPK1 MAPK13 MAX MDM4 MECOM MEF2A MEX3B MYOD1 NAT8 NEK6 NELFCD NF1 NKX3-2 NOTCH4 NR0B2 NRAS NUAK2 NUP214 OTUB1 PAK1 PAPPA2 PARD3 PARD3B PBK PIAS1 PIAS2 PIAS3 PIAS4 PLG PLK4 PRKAR1B PRKAR2A PRPF40A PSG2 PSG9 PSMD11 RAB13 RAB25 RAB2B RAB34 RAB38 RAB3B RAC2 RALA RASD2 RASL12 RASSF5 RBL1 RELA RFX1 RHEBL1 RHOD RHOG RHOJ RIPK2 RMND5B RPL28 RPS27A RRAS2 RSPH14 SASH3 SERPINA1 SKI SKIL SKP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD7 SMAD9 SNIP1 SNRNP70 SNW1 SOX12 SP1 SPTBN1 SQSTM1 STK11IP STK35 STUB1 TCTA TDG TENM3 TFE3 TGFBR1 TGFBR2 TGFBRAP1 TM9SF2 TOB1 TRAP1 TSSK3 UBA52 UBB UBE2I UBE2L3 UBE2Z UHRF2 USB1 USP9X XPO5 ZBED5 ZMYM2 ZNF423 ZNF521 ZNF8	35 interactors: ANXA7 ARRB1 ATN1 AXIN1 BRD7 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FRAT1 HDHD2 HECW1 LRRK2 NCK2 NEDD4 PPM1A PSMA3 RAC1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 TRIM69 USP13 VANGL1 VANGL2
Entrez ID		4089	1855
HPRD ID		02995	03220
Ensembl ID		ENSG00000141646	ENSG00000107404
Uniprot IDs		Q13485	O14640 Q86TH3
PDB IDs		1DD1 1G88 1MR1 1U7F 1U7V 1YGS
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Signaling Response To Transforming Growth Factor Beta Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process	Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Morphogenesis Regulation Of Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Modification Process SMAD Protein Complex Assembly Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Signaling Regulation Of Proteasomal Protein Catabolic Process Cell Communication Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Stem Cell Differentiation Embryonic Axis Specification Regulation Of Phosphorus Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Kidney Development
Tagcloud ?		adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad3 smads squelching tgf transactivation transduce	1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic
Tagcloud (Difference) ?		adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad3 smads squelching tgf transactivation transduce	1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic
Tagcloud (Intersection) ?