LTBP1 and ITGB5

Number of citations of the paper that reports this interaction (PMID 12358597)
23

Data Source:
HPRD (in vitro, in vivo)

		LTBP1	ITGB5
Gene Name		latent transforming growth factor beta binding protein 1	integrin, beta 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Protein Complex	Plasma Membrane Focal Adhesion Cell Surface Cell Leading Edge Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding Microfibril Binding	Receptor Activity Integrin Binding Protein Binding
	Biological Process	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Matrix Organization Sequestering Of TGFbeta In Extracellular Matrix	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Muscle Contraction Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Extracellular Matrix Organization Endodermal Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Stress Fiber Assembly Epithelial Cell-cell Adhesion
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Elastic fibre formation Smooth Muscle Contraction Non-integrin membrane-ECM interactions Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS		Height ( 20881960 19893584 23563607 20189936) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502)
Protein-Protein Interactions		9 interactors: ATN1 CACNA1A FBN1 FBN2 FN1 IGFBP3 ITGB5 TGFB1 TGM2	34 interactors: ANXA5 CYR61 DAB1 DAB2 DOK1 EHMT2 EPS8 EWSR1 FHL2 FLNA GNB2L1 ITGA5 ITGAV ITGB3BP KRT40 KRTAP10-8 KRTAP10-9 LTBP1 LTBP3 MTUS2 MYO10 NOTCH2NL NUMB P2RY2 PAK4 PALLD PIAS2 PPARD PTK2 SNTA1 SRSF9 TLN1 TNS2 ZBTB17
Entrez ID		4052	3693
HPRD ID		01039	00949
Ensembl ID		ENSG00000049323	ENSG00000082781
Uniprot IDs		B7ZLY3 Q14766	L7RT22 P18084
PDB IDs		1KSQ
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Sequestering Of TGFbeta In Extracellular Matrix Developmental Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Endoderm Development Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Extracellular Negative Regulation Of Signal Transduction Anatomical Structure Development Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Anatomical Structure Morphogenesis Endodermal Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Myoblast Differentiation Positive Regulation Of Biomineral Tissue Development Salivary Gland Morphogenesis Regulation Of Cell Differentiation Peptide Cross-linking System Development Salivary Gland Development Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Cell Differentiation Endoderm Formation Exocrine System Development Exocytosis Regulation Of Cell Growth Regulation Of Signaling Cellular Component Assembly Platelet Degranulation Regulation Of Bone Mineralization Cellular Metal Ion Homeostasis Cerebellar Molecular Layer Development Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Cell Death Death Negative Regulation Of Signal Transduction Positive Regulation Of Muscle Cell Differentiation Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis	Signaling Cell Communication Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Locomotion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Cell Migration Wound Healing Cell Development Regulation Of Cell Motility Movement Of Cell Or Subcellular Component Regulation Of Locomotion Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Positive Regulation Of Protein Phosphorylation Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Cell Migration Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Chemotaxis Positive Regulation Of Phosphorylation Axon Guidance Multicellular Organismal Development Regulation Of Cell Adhesion Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Blood Coagulation Negative Regulation Of Programmed Cell Death Hemostasis Developmental Process Anatomical Structure Development Apoptotic Process Positive Regulation Of Protein Kinase Activity Programmed Cell Death Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Cell Morphogenesis
Tagcloud ?		besides bioactive bioinformatics btb btbd3 candidate connectivity cul3 degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
Tagcloud (Difference) ?		besides bioactive bioinformatics btb btbd3 candidate connectivity cul3 degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
Tagcloud (Intersection) ?