LRP1 and SYNJ2BP

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		LRP1	SYNJ2BP
Gene Name		low density lipoprotein receptor-related protein 1	synaptojanin 2 binding protein
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Mitochondrion Cell Surface Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	Protein C-terminus Binding Type II Activin Receptor Binding
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Positive Regulation Of Receptor Internalization Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Intracellular Distribution Of Mitochondria Positive Regulation Of Protein Localization To Cell Surface
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	10 interactors: ACTB ACVR2A ACVR2B APP LRP1 LRP2 LRP8 RALBP1 SYNJ2 USHBP1
Entrez ID		4035	55333
HPRD ID		00138	15455
Ensembl ID		ENSG00000123384
Uniprot IDs		Q07954 Q59FG2	P57105
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY	2ENO 2JIK 2JIN
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Endocytosis Phototransduction, Visible Light Positive Regulation Of Activin Receptor Signaling Pathway Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Response To Light Stimulus Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Response To External Stimulus Response To Radiation Regulation Of Activin Receptor Signaling Pathway Detection Of Abiotic Stimulus Signal Transduction Lipid Metabolic Process Activin Receptor Signaling Pathway Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Signaling Vesicle-mediated Transport Cell Communication Steroid Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Brain Development System Development Head Development Mating Gastrulation With Mouth Forming Second Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Organ Development Cellular Response To Stimulus Receptor-mediated Endocytosis Artery Development Regulation Of Signaling Cellular Lipid Metabolic Process Central Nervous System Development Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Anatomical Structure Development Ammon Gyrus Development Beta-amyloid Clearance Regulation Of Protein Phosphorylation Transport Blood Coagulation
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Intersection) ?