LIG4 and MCM4

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		LIG4	MCM4
Gene Name		ligase IV, DNA, ATP-dependent	minichromosome maintenance complex component 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Nucleus Nucleoplasm Membrane MCM Complex
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Ligation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Proliferation Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion DNA Biosynthetic Process Establishment Of Integrated Proviral Latency	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication
Pathways		HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		103 interactors: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 CAP1 CCDC176 CLU COL1A2 COMMD1 COX1 COX2 COX3 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C ND1 ND4 ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	24 interactors: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 SSRP1 SUPT16H TLX2
Entrez ID		3981	4173
HPRD ID		03500	09094
Ensembl ID		ENSG00000174405	ENSG00000104738
Uniprot IDs		P49917	B3KMX0 B4DLA6 P33991
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization DNA Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress Metabolic Process Cell Cycle Process Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Response To Stress Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Mitochondrial Electron Transport, NADH To Ubiquinone Mitotic Cell Cycle Checkpoint Positive Regulation Of Signal Transduction By P53 Class Mediator Viral Process Response To Radiation Mitotic Cell Cycle Process Protein Metabolic Process Negative Regulation Of Cell Cycle Response To Gamma Radiation Posttranscriptional Regulation Of Gene Expression Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Translation Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Electron Transport Chain Regulation Of Protein Ubiquitination Regulation Of Response To DNA Damage Stimulus Cell Cycle V(D)J Recombination Pro-B Cell Differentiation Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Ubiquitin-protein Transferase Activity	DNA Replication G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair Chromosome Organization Cellular Response To Stress Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process DNA Unwinding Involved In DNA Replication Double-strand Break Repair Nucleotide-excision Repair, DNA Gap Filling DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition DNA Recombination DNA Conformation Change Regulation Of Cell Cycle Process Regulation Of DNA Replication DNA Recombinase Assembly Organelle Organization DNA Damage Checkpoint Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Cell Cycle Metabolic Process Response To Stress Positive Regulation Of DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Mitotic Cell Cycle
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	adh8l alveolus bmp16 clu1 clu2 coho col1a1 col1a2 cyp19a1a dcn ddit4l droplet fishes fn1 fsh fshr inha ivns1abpa maturing oogenesis perinucleolus pim1 salmon smad5l steroidogenesis suite vitellogenic wapl wt2l
Tagcloud (Difference) ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	adh8l alveolus bmp16 clu1 clu2 coho col1a1 col1a2 cyp19a1a dcn ddit4l droplet fishes fn1 fsh fshr inha ivns1abpa maturing oogenesis perinucleolus pim1 salmon smad5l steroidogenesis suite vitellogenic wapl wt2l
Tagcloud (Intersection) ?