KPNA2 and SLC2A2

Number of citations of the paper that reports this interaction (PMID 11988093)
13

Data Source:
BioGRID (pull down, affinity chromatography technology, two hybrid)
HPRD (two hybrid, in vitro, in vivo)

		KPNA2	SLC2A2
Gene Name		karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	solute carrier family 2 (facilitated glucose transporter), member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding	Glucose Transmembrane Transporter Activity Hexose Transmembrane Transporter Activity Dehydroascorbic Acid Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway	Carbohydrate Metabolic Process Energy Reserve Metabolic Process Hexose Transport Pathogenesis Glucose Transport Endocrine Pancreas Development Hexose Transmembrane Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Dehydroascorbic Acid Transport
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Integration of energy metabolism Regulation of insulin secretion Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport Hexose transport Regulation of beta-cell development Myoclonic epilepsy of Lafora Facilitative Na+-independent glucose transporters Glycogen storage diseases Regulation of gene expression in beta cells Glucose transport Metabolism of carbohydrates
Drugs			Streptozocin
Diseases
GWAS			Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	4 interactors: APP KPNA2 PDX1 PRKACA
Entrez ID		3838	6514
HPRD ID		02818	00685
Ensembl ID		ENSG00000182481	ENSG00000163581
Uniprot IDs		P52292 Q7Z726	B7Z547 F8W8V8 P11168 Q6PAU8
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 4E4V
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development	Regulation Of Binding Regulation Of Cellular Ketone Metabolic Process Response To Wounding Response To Cytokine Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Dense Core Granule Biogenesis Response To Glucose Chemical Homeostasis Second-messenger-mediated Signaling Glucose Metabolic Process Regulation Of Protein Binding Cell Maturation Morphogenesis Of Embryonic Epithelium Cell Surface Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Organ Senescence Histone H3-T6 Phosphorylation Response To Carbohydrate Platelet Activation Regulation Of Insulin Secretion Glucose Homeostasis Hexose Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Collateral Sprouting In Absence Of Injury Detection Of Glucose Regulation Of Peptide Hormone Secretion Positive Regulation Of Cell Cycle Process Response To Chlorate Monosaccharide Metabolic Process Regulation Of Hormone Secretion Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Iron(II) Ion Regulation Of Phosphorus Metabolic Process Calcium Ion Homeostasis Response To Leucine Peptidyl-serine Autophosphorylation Axon Choice Point Recognition Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Protein Transport Positive Regulation Of Cellular Biosynthetic Process Response To Light Stimulus Extracellular Matrix Organization
Tagcloud ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	aav abcc8 adeno administrations cxcl12 cxcl13 damaged fkbp1b foxa2 g6pc2 gad1 glp glucosamine glut2 isl1 islets neurod1 nitrosourea nkx6 nptx2 pdx1 preserve prss53 sdf slc30a8 stz tmem229b ttc28 ucn3
Tagcloud (Difference) ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	aav abcc8 adeno administrations cxcl12 cxcl13 damaged fkbp1b foxa2 g6pc2 gad1 glp glucosamine glut2 isl1 islets neurod1 nitrosourea nkx6 nptx2 pdx1 preserve prss53 sdf slc30a8 stz tmem229b ttc28 ucn3
Tagcloud (Intersection) ?