JUNB and FOSL2

Number of citations of the paper that reports this interaction (PMID 19321746)
17

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		JUNB	FOSL2
Gene Name		jun B proto-oncogene	FOS-like antigen 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleoplasm	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Vasculogenesis Osteoblast Differentiation Trophectodermal Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Response To Light Stimulus Response To Mechanical Stimulus Gene Expression Osteoclast Differentiation Response To Progesterone Cellular Response To Hormone Stimulus Osteoblast Proliferation Response To Cytokine Response To Drug Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Decidualization Response To Corticosterone Response To CAMP Regulation Of Cell Cycle Embryonic Process Involved In Female Pregnancy Labyrinthine Layer Blood Vessel Development Cellular Response To Calcium Ion Negative Regulation Of Nucleic Acid-templated Transcription	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Female Pregnancy Cell Death Response To Mechanical Stimulus Response To Progesterone Cellular Response To Hormone Stimulus Response To Drug Response To Morphine Positive Regulation Of Fibroblast Proliferation Response To Corticosterone Response To CAMP
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		37 interactors: APLP2 ATF3 ATF4 BATF BATF2 BATF3 BCL6 BDNF BRCA1 C19orf68 DDIT3 EP300 ESR1 FOS FOSB FOSL1 FOSL2 HOXA7 JDP2 MAP2 MAPK14 MAPK6 MAPK8 MAPK9 NEU1 NFE2L1 NINL PKIA SAT1 SET SMAD3 SMAD4 SMURF1 TCERG1 TDG USP24 ZNF595	13 interactors: CREB5 DDIT3 DNAJA3 EP300 FHL3 GMCL1 GOPC JUN JUNB JUND LUZP4 SRA1 TRAF1
Entrez ID		3726	2355
HPRD ID		01303	03343
Ensembl ID		ENSG00000171223
Uniprot IDs		P17275 Q5U079	P15408 Q9H5M2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Response To External Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Lipid Response To Mechanical Stimulus Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Response To Abiotic Stimulus Developmental Process Response To Corticosterone Response To Biotic Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Response To Mineralocorticoid Positive Regulation Of Cellular Biosynthetic Process	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Developmental Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Response To Calcium Ion Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Apoptotic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation By Host Of Viral Transcription Positive Regulation Of Transcription, DNA-templated Response To Calcium Ion Regulation Of Metabolic Process Cellular Response To Metal Ion Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Inorganic Substance Positive Regulation Of Gene Expression Cell Differentiation RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Response To Endoplasmic Reticulum Stress Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Circadian Rhythm Positive Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Response To Abiotic Stimulus Interaction With Symbiont Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Mechanical Stimulus Positive Regulation Of Viral Transcription Negative Regulation Of Biosynthetic Process RNA Metabolic Process Positive Regulation Of Neuron Apoptotic Process Rhythmic Process Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Aging
Tagcloud ?		accumulated amplified clones delay differentiate differentiative ectopic epo erythroid erythropoietin evaluating g418 grow heavy introduced lg modifies modify neither plasmacytoma proliferated proliferative providing responsive retrovirally stat5 tepc transduced varied	acetylation antigen ap belongs beta1 correlates diverse facilitates fra indicates interacts little mechanistically migration nsclc p300 pathological physiological processes promotes regulate regulates show signalling smad3 suggests summary tgf
Tagcloud (Difference) ?		accumulated amplified clones delay differentiate differentiative ectopic epo erythroid erythropoietin evaluating g418 grow heavy introduced lg modifies modify neither plasmacytoma proliferated proliferative providing responsive retrovirally stat5 tepc transduced varied	acetylation antigen ap belongs beta1 correlates diverse facilitates fra indicates interacts little mechanistically migration nsclc p300 pathological physiological processes promotes regulate regulates show signalling smad3 suggests summary tgf
Tagcloud (Intersection) ?