JAK1 and CXCR4

Number of citations of the paper that reports this interaction (PMID 12163560)
16

Data Source:
HPRD (in vivo)

		JAK1	CXCR4
Gene Name		Janus kinase 1	chemokine (C-X-C motif) receptor 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Endomembrane System Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Growth Cone Cell Leading Edge Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Protein Phosphatase Binding CCR5 Chemokine Receptor Binding	Virus Receptor Activity Actin Binding G-protein Coupled Receptor Activity Protein Binding Coreceptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding Ubiquitin Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Interleukin-2-mediated Signaling Pathway Regulation Of Cell Proliferation Innate Immune Response Response To Antibiotic Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Activation Of MAPK Activity Patterning Of Blood Vessels Response To Hypoxia Ameboidal-type Cell Migration Neuron Migration Dendritic Cell Chemotaxis Apoptotic Process Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Germ Cell Development Brain Development Motor Neuron Axon Guidance Germ Cell Migration Response To Virus Viral Process Calcium-mediated Signaling Entry Into Host Cell Regulation Of Cell Migration T Cell Proliferation Neutrophil Activation Myelin Maintenance Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Chemotaxis Neural Precursor Cell Proliferation Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Interferon gamma signaling Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Interleukin-7 signaling SOS-mediated signalling SHC-mediated signalling TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation GPCR downstream signaling Signaling by VEGF Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Downstream signal transduction Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade ISG15 antiviral mechanism Interferon Signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling GPVI-mediated activation cascade Signaling by GPCR FCERI mediated MAPK activation SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Toll Like Receptor 9 (TLR9) Cascade Signaling by PDGF DAP12 interactions Regulation of IFNA signaling G-protein beta:gamma signalling GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation G beta:gamma signalling through PI3Kgamma Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer ERK2 activation SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling ERK2 activation Regulation of IFNG signaling	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs			Framycetin Plerixafor
Diseases
GWAS			Multiple sclerosis ( 19525953) Telomere length ( 20421499)
Protein-Protein Interactions		69 interactors: ABL1 BRCA1 BTK CCR1 CCR5 CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GHR GNB2L1 GRB2 HIST3H3 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2	32 interactors: ADRBK2 ARRB2 ATP13A2 CCR5 CD4 CTSG CXCL12 DPP4 ELANE GNA13 GNAI1 HLA-C HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		3716	7852
HPRD ID		00992	01217
Ensembl ID		ENSG00000162434	ENSG00000121966
Uniprot IDs		P23458	P61073
PDB IDs		3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01	2K03 2K04 2K05 3ODU 3OE0 3OE6 3OE8 3OE9
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Response To Organic Substance Response To Cytokine Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Defense Response Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Immune System Process Immune Response Cellular Response To Stimulus Innate Immune Response Response To Stimulus Intracellular Signal Transduction Cellular Response To Organonitrogen Compound JAK-STAT Cascade Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cell Proliferation Cellular Response To Growth Hormone Stimulus Response To Stress Cellular Response To Peptide Regulation Of Cell Activation Regulation Of Signal Transduction Response To Organonitrogen Compound Regulation Of Signaling Response To Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Peptide Hormone Peptidyl-tyrosine Phosphorylation Response To Peptide Response To Growth Hormone Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cell Activation Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Immune Response Regulation Of Immune System Process Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Stress Defense Response JAK-STAT Cascade Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Immune Response Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Innate Immune Response Regulation Of Cell-cell Adhesion Locomotion Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Regulation Of Type I Interferon-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Response To Peptide Hormone Regulation Of Cell Adhesion Innate Immune Response Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Peptide Signaling Movement Of Cell Or Subcellular Component Response To Type I Interferon Cell Migration Positive Regulation Of Cell Adhesion Cell Communication Response To External Stimulus Cell Activation Positive Regulation Of Immune System Process Interferon-gamma-mediated Signaling Pathway Cell Motility Response To Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Interferon-gamma Regulation Of Signal Transduction Signal Transduction Cellular Response To Organic Substance Response To Interferon-gamma
Tagcloud ?		2c4 assign b10 b3 b9 cd2 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	capture ccr1 ccr2 ccr5 ccr7 cd40 chemokine chemokines cxcr1 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness
Tagcloud (Difference) ?		2c4 assign b10 b3 b9 cd2 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn oas oligoadenylate pairwise permitted restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	capture ccr1 ccr2 ccr5 ccr7 cd40 chemokine chemokines cxcr1 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded
Tagcloud (Intersection) ?		responsiveness