ITGB7 and TNS2

Number of citations of the paper that reports this interaction (PMID 12606711)
66

Data Source:
HPRD (in vitro)

		ITGB7	TNS2
Gene Name		integrin, beta 7	tensin 2
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Vesicular Exosome	Plasma Membrane Focal Adhesion
	Molecular Function	Virus Receptor Activity Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Phosphoprotein Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Multicellular Organismal Development Response To Virus Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Regulation Of Immune Response Leukocyte Tethering Or Rolling T Cell Migration	Kidney Development Negative Regulation Of Cell Proliferation Response To Muscle Activity Dephosphorylation Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Intracellular Signal Transduction Multicellular Organismal Homeostasis
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: CDH1 DAB1 DOK1 EED FLNA FN1 GNB2L1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD TLN1 TNS2 VCAM1	28 interactors: AXL BRCA1 C11orf87 C19orf66 CRKL CSNK1E ERBB2 ERBB3 FGFR1 GFI1B ITGB3 ITGB5 ITGB7 KIF1A KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 NUBP2 PKP1 REEP6 REL TBC1D16 TEKT5 ZNF250 ZNF417 ZNF587
Entrez ID		3695	23371
HPRD ID		00948	16256
Ensembl ID		ENSG00000139626	ENSG00000111077
Uniprot IDs		P26010	Q63HR2
PDB IDs		2BRQ 3V4P 3V4V	2DKQ 2KNO 2L6K 2LOZ 3HQC
Enriched GO Terms of Interacting Partners?		Cell Adhesion Regulation Of Body Fluid Levels Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Tethering Or Rolling Cell Activation Platelet Activation Blood Coagulation Hemostasis Single Organismal Cell-cell Adhesion Cellular Extravasation Wound Healing Positive Regulation Of Cellular Protein Metabolic Process B Cell Activation Response To Wounding Cell-matrix Adhesion Positive Regulation Of Protein Metabolic Process Receptor Clustering Cell Junction Assembly Cell-substrate Adhesion Regulation Of Immune Response Leukocyte Migration Positive Regulation Of Protein Modification Process Platelet Degranulation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Chorio-allantoic Fusion Regulation Of Protein Metabolic Process Signal Transduction Regulation Of Cellular Process Anatomical Structure Morphogenesis Cellular Response To Stimulus Response To Stimulus Developmental Process Cell Differentiation Cell Morphogenesis Involved In Differentiation Integrin-mediated Signaling Pathway Protein Localization To Membrane Signaling Locomotion Cell Communication Regulation Of Immune System Process Regulation Of Cellular Protein Metabolic Process Labyrinthine Layer Morphogenesis Heterotypic Cell-cell Adhesion Lymphocyte Activation Multicellular Organismal Development Cell Migration Membrane Organization Embryonic Placenta Morphogenesis	Immune System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cell-substrate Adhesion Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Modification Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Regulation Of Histone H3-K4 Methylation Integrin-mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase III Promoter Heterotypic Cell-cell Adhesion Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Process Phosphatidylinositol-mediated Signaling Signal Transduction Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-matrix Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Innate Immune Response Cell Surface Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Multicellular Organismal Development Intracellular Signal Transduction Cellular Response To Organic Substance Viral Entry Into Host Cell Positive Regulation Of Phosphorylation Response To Organic Substance
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