ARAF and CPS1

Number of citations of the paper that reports this interaction (PMID 12620389)
9

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARAF	CPS1
Gene Name		A-Raf proto-oncogene, serine/threonine kinase	carbamoyl-phosphate synthase 1, mitochondrial
Image
Gene Ontology Annotations	Cellular Component	Cellular_component	Nucleolus Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Nucleoid Protein Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Activity Protein Binding ATP Binding Metal Ion Binding	Carbamoyl-phosphate Synthase (ammonia) Activity Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity Endopeptidase Activity Calcium Ion Binding Protein Binding ATP Binding Phospholipid Binding Glutamate Binding Protein Complex Binding Modified Amino Acid Binding
	Biological Process	Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process	Urea Cycle Glycogen Catabolic Process Proteolysis Arginine Biosynthetic Process Glutamine Catabolic Process Midgut Development Response To Toxic Substance Response To Zinc Ion Response To Amine Citrulline Biosynthetic Process Triglyceride Catabolic Process Response To Food Response To Lipopolysaccharide Cellular Nitrogen Compound Metabolic Process Response To Drug Response To Starvation Response To Amino Acid Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Vasodilation Nitric Oxide Metabolic Process Homocysteine Metabolic Process Anion Homeostasis Response To Growth Hormone Hepatocyte Differentiation Carbamoyl Phosphate Biosynthetic Process Cellular Response To CAMP Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Response To Dexamethasone
Pathways			Urea cycle Metabolism of amino acids and derivatives
Drugs		Adenosine triphosphate
Diseases
GWAS			Body mass index (asthmatics) ( 23517042) Chronic kidney disease ( 20383146) Fibrinogen ( 20031577) Homocysteine levels ( 20154341) Metabolic traits ( 21886157) Metabolite levels ( 23378610) Non-small cell lung cancer ( 23144319)
Protein-Protein Interactions		38 interactors: AGTRAP ASS1 BAD CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS MAP2K1 MAP2K2 MLH1 MYO18A NELFCD NUDT14 PBK PDGFRB PIK3R1 PKM PRPF6 RABGGTB RGS12 RRAS RRAS2 TEKT4P2 TESK1 TIMM44 TIRAP WNK1 YWHAG YWHAZ	2 interactors: ARAF RAF1
Entrez ID		369	1373
HPRD ID		02405	01995
Ensembl ID		ENSG00000078061	ENSG00000021826
Uniprot IDs		B4DV85 P10398 Q96II5	B7ZAW0 P31327 Q6PEK7
PDB IDs		1WXM	2YVQ
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cellular Response To Peptide Hormone Stimulus Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Signal Transduction Cellular Response To Peptide Cellular Response To Organonitrogen Compound Immune Response Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Regulation Of Locomotion Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Component Movement Signaling Response To Hormone Regulation Of Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Cell Migration Phosphorylation Response To Stimulus Regulation Of MAPK Cascade Response To Oleic Acid Intrinsic Apoptotic Signaling Pathway Response To Peptide Hormone Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Response To Peptide Positive Regulation Of Cell Motility Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Movement Positive Regulation Of MAP Kinase Activity Cellular Response To Insulin Stimulus	Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Death-inducing Signaling Complex Assembly Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Metabolic Process Activation Of Adenylate Cyclase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Regulation Of Phosphorylation Protein Phosphorylation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Apoptotic Process Positive Regulation Of Lyase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Death Regulation Of Adenylate Cyclase Activity Regulation Of TOR Signaling Positive Regulation Of CAMP Biosynthetic Process Activation Of MAPKK Activity Regulation Of Cyclase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of CAMP Metabolic Process Somatic Stem Cell Maintenance Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Complex Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w	aberrations applying arid2 axin1 cdk15 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Difference) ?		al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w	aberrations applying arid2 axin1 cdk15 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Intersection) ?