ITGA5 and ITGB1

Number of citations of the paper that reports this interaction (PMID 7504269)
48

Data Source:
HPRD (in vivo, in vitro)

		ITGA5	ITGB1
Gene Name		integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
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Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Ruffle Membrane Synapse Alphav-beta3 Integrin-vitronectin Complex	Acrosomal Vesicle Ruffle Basement Membrane Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Intercalated Disc Membrane Lamellipodium Hemidesmosome Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Dendritic Spine Receptor Complex Membrane Raft Recycling Endosome Extracellular Vesicular Exosome Invadopodium Membrane Synaptic Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	Virus Receptor Activity Glycoprotein Binding Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Peptide Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Alpha-actinin Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Memory Positive Regulation Of Cell-substrate Adhesion Viral Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Negative Regulation Of Anoikis	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Cell Fate Specification Tissue Homeostasis Cell Migration Involved In Sprouting Angiogenesis Cellular Calcium Ion Homeostasis Cellular Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Germ Cell Migration Visual Learning Response To Virus Regulation Of Collagen Catabolic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Response To Activity Viral Process Cell Migration Formation Of Radial Glial Scaffolds B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Projection Organization Cell-substrate Adhesion Protein Transport Within Lipid Bilayer Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Cell Junction Assembly Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Response To Drug Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAPK Cascade Sarcomere Organization Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Mesodermal Cell Differentiation Axon Extension Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Cardiac Muscle Cell Differentiation Maternal Process Involved In Female Pregnancy Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Vitamin D Cellular Response To Ionizing Radiation Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Anoikis
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation Fibronectin matrix formation L1CAM interactions Integrin cell surface interactions Cell surface interactions at the vascular wall	Platelet Adhesion to exposed collagen Axon guidance Elastic fibre formation L1CAM interactions Molecules associated with elastic fibres Laminin interactions ECM proteoglycans Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell junction organization Signal transduction by L1 Semaphorin interactions Other semaphorin interactions Non-integrin membrane-ECM interactions Basigin interactions Cell surface interactions at the vascular wall Syndecan interactions CHL1 interactions Integrin cell surface interactions Cell-extracellular matrix interactions Adaptive Immune System
Drugs
Diseases
GWAS			Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		24 interactors: ANGPT1 ANGPTL3 ARHGAP5 AUP1 CD9 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM NISCH PECAM1 RABIF SPP1 STAMBP TNC	67 interactors: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CRKL DAG1 DOK1 EPS8 FBLN1 FBXO2 FHL2 FLNA FLNB FLT4 FN1 GNB2L1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LGALS1 LGALS3BP LGALS8 MAP4K4 NCKIPSD NF2 NME1 NMRK2 PDHB PLAUR PRKCA PRKCE PTK2 PXN RAB25 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 UPF2 VCAM1 VCAN YWHAB
Entrez ID		3678	3688
HPRD ID		00627	00628
Ensembl ID		ENSG00000161638	ENSG00000150093
Uniprot IDs		P08648	P05556
PDB IDs		3VI3 3VI4	1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Migration Regulation Of Cell Motility Cardiovascular System Development Regulation Of Locomotion Regulation Of Cellular Component Movement Blood Vessel Development Vasculature Development Leukocyte Migration Response To Stimulus Positive Regulation Of Cell Proliferation Wound Healing Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Response To Wounding Cell-substrate Adhesion Cell Migration Response To Growth Factor Movement Of Cell Or Subcellular Component Multicellular Organismal Development Blood Vessel Morphogenesis Blood Coagulation Cell Motility Hemostasis System Development Anatomical Structure Development Cellular Response To Stimulus Locomotion Cell Communication Positive Regulation Of Signal Transduction Regulation Of Signaling Cell-matrix Adhesion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Developmental Process Response To Vitamin Response To Nutrient Regulation Of Body Fluid Levels Signaling Cell Activation Regulation Of Cellular Process Formation Of Primary Germ Layer Signal Transduction	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Cell-matrix Adhesion Cell-substrate Adhesion Wound Healing Response To Wounding Regulation Of Body Fluid Levels Multicellular Organismal Development Movement Of Cell Or Subcellular Component Anatomical Structure Development Locomotion System Development Developmental Process Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Cell Migration Leukocyte Migration Cell Motility Signal Transduction Cell Junction Assembly Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Signaling Response To Stimulus Positive Regulation Of Locomotion Regulation Of Cell Motility Cell Communication Cell Activation Regulation Of Locomotion Regulation Of Cell-substrate Adhesion Platelet Activation Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Process Cell Morphogenesis Response To Stress
Tagcloud ?			124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Difference) ?			124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Intersection) ?