FAS and FAF1

Number of citations of the paper that reports this interaction (PMID 9740801)
97

Data Source:
HPRD (in vivo)

		FAS	FAF1
Gene Name		Fas cell surface death receptor	Fas (TNFRSF6) associated factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Vesicular Exosome	Nucleus Nuclear Envelope Cytosol CD95 Death-inducing Signaling Complex Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Identical Protein Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	Immunoglobulin Production Renal System Process Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Cell Apoptotic Process Transformed Cell Apoptotic Process Signal Transduction Circadian Rhythm Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Toxic Substance B Cell Mediated Immunity Positive Regulation Of Protein Homooligomerization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Spleen Development Negative Regulation Of B Cell Activation Protein Homooligomerization Response To Glucocorticoid Cellular Response To Mechanical Stimulus Cellular Response To Lithium Ion Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Atrioventricular conduction ( 21041692) Immunoglobulin A ( 20694011) Obesity-related traits ( 23251661)	Depression and alcohol dependence ( 22064162) Ventricular conduction ( 21076409)
Protein-Protein Interactions		48 interactors: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK C14orf1 CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX EEF1A1 EGFR EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC KRIT1 LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 UBA7 UBE2I UBQLN1	37 interactors: ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 TAF1D TK1 TNNT1 TSC22D1 UROD VAPB
Entrez ID		355	11124
HPRD ID		00609	05124
Ensembl ID		ENSG00000026103	ENSG00000185104
Uniprot IDs		P25445	B4DEJ6 Q9UNN5
PDB IDs		1BZI 1DDF 3EWT 3EZQ 3THM 3TJE	1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Catalytic Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Macrophage Differentiation Response To Mechanical Stimulus Positive Regulation Of Hydrolase Activity Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Regulation Of Protein Kinase Activity Immune Response	Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Cyclic Compound Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Response To Lipid Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Steroid Hormone Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Establishment Of Protein Localization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Endopeptidase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Peptidase Activity Response To External Stimulus Regulation Of Protein Localization Regulation Of Cellular Localization Leukocyte Homeostasis Regulation Of Immune System Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Kinase Activity Cell Communication Intracellular Receptor Signaling Pathway
Tagcloud ?		activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Difference) ?		activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Intersection) ?		fas