IFI27 and CCND1

Number of citations of the paper that reports this interaction (PMID 9837900)
10

Data Source:
HPRD (in vivo)

		IFI27	CCND1
Gene Name		interferon, alpha-inducible protein 27	cyclin D1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane	Cyclin-dependent Protein Kinase Holoenzyme Complex Intracellular Nucleus Nucleoplasm Cytosol Tight Junction Membrane Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Molecular_function Lamin Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Protein Complex Binding Histone Deacetylase Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cytokine-mediated Signaling Pathway Regulation Of Protein Export From Nucleus Type I Interferon Signaling Pathway Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Re-entry Into Mitotic Cell Cycle Liver Development Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Response To Corticosterone Response To Calcium Ion Canonical Wnt Signaling Pathway Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Chromatin organization Signaling by NOTCH Ubiquitin-dependent degradation of Cyclin D G1 Phase S Phase Cell Cycle, Mitotic RMTs methylate histone arginines Ubiquitin-dependent degradation of Cyclin D1 Cyclin D associated events in G1 Chromatin modifying enzymes Pre-NOTCH Transcription and Translation Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases
Drugs			Arsenic trioxide
Diseases
GWAS			Breast cancer ( 20453838) Breast size ( 22747683) Multiple myeloma (IgH translocation) ( 23502783)
Protein-Protein Interactions		2 interactors: CCND1 CDK4	60 interactors: AKAP8 AR ARID4A ATF2 BRCA1 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CRYAB CTNNB1 CUL3 DMTF1 EP300 ESR1 FBXO31 FBXO4 GSK3B HDAC3 HERC5 IFI27 INSM1 KAT2B LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PRKACA RABEP1 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SP1 STAT3 TAF1 THRA THRB TP73 TSC2 UBTF UHRF2 USP2 XPO1
Entrez ID		3429	595
HPRD ID		02479	01346
Ensembl ID		ENSG00000165949	ENSG00000110092
Uniprot IDs		A8K0H0 P40305	P24385 Q6FI00
PDB IDs			2W96 2W99 2W9F 2W9Z
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Arrest Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Organ Regeneration Regulation Of Cell Cycle Arrest Positive Regulation Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Response To Metal Ion Re-entry Into Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Cell Cycle Response To Inorganic Substance Response To Steroid Hormone Regulation Of Cell Cycle Process Response To UV-A Response To Drug Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Cell Size Mitotic Cell Cycle Process Chromatin Organization Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Response To Lipid Response To Organic Cyclic Compound Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Cycle Response To Magnesium Ion Response To Hormone Response To Vitamin E Leydig Cell Differentiation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mammary Gland Epithelial Cell Proliferation Chromosome Organization Cell Cycle Process Regulation Of Protein Phosphorylation Response To Lead Ion Response To Abiotic Stimulus Response To Hyperoxia	Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Organic Substance Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cell Cycle Arrest Transcription, DNA-templated Cellular Response To Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Kinase Activity RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Kinase Activity Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process
Tagcloud ?		activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma ifit1 irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1 trail	11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold
Tagcloud (Difference) ?		activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma ifit1 irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1 trail	11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold
Tagcloud (Intersection) ?