IFI16 and ID3

Number of citations of the paper that reports this interaction (PMID 11940648)
13

Data Source:
HPRD (in vitro, in vivo)

		IFI16	ID3
Gene Name		interferon, gamma-inducible protein 16	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Double-stranded DNA Binding Protein Binding Transcription Factor Binding Identical Protein Binding Poly(A) RNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Transcription, DNA-templated Autophagy Inflammatory Response Cell Proliferation Regulation Of Autophagy Hemopoiesis Myeloid Cell Differentiation Monocyte Differentiation Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Gene Expression, Epigenetic Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Binding Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Regulation Of DNA Replication Transcription, DNA-templated Multicellular Organismal Development Central Nervous System Development Heart Development Muscle Organ Development Circadian Rhythm Response To Wounding Neuron Differentiation Epithelial Cell Differentiation Notochord Development Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle
Pathways		Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS		C-reactive protein ( 22939635) Celiac disease and Rheumatoid arthritis ( 21383967) Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: APP AR BRCA1 CSNK2A1 ID1 ID2 ID3 TP53 TP53BP1 TPR	36 interactors: ADD1 ATF3 CBFA2T2 CDK2 CNOT3 CSK E2F4 ELK1 ELK4 FAM74A1 FHL2 GATA4 GNB2 GTF2A1L HES1 ID4 IFI16 IKBKG MLX MYF5 MYF6 MYOD1 MYOG PAX5 PRDM14 PUF60 RND1 RUNX1T1 SAP30 SREBF1 TCF12 TCF3 TCF4 ZNF3 ZNF408 ZNF626
Entrez ID		3428	3399
HPRD ID		00969	02608
Ensembl ID		ENSG00000163565	ENSG00000117318
Uniprot IDs		Q16666	Q02535
PDB IDs		2OQ0 3B6Y 3RLN 3RLO 3RNU	2LFH
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Regulation Of Mitotic Cell Cycle RNA Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Regulation Of Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Cycle Arrest Negative Regulation Of Ossification Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Chromosome Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Cell Cycle Arrest Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Apoptotic Process Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process	Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Muscle Structure Development Skeletal Muscle Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Cellular Process Positive Regulation Of Skeletal Muscle Fiber Development Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Cell Fate Commitment Negative Regulation Of Transcription From RNA Polymerase II Promoter Striated Muscle Tissue Development Multicellular Organismal Development Muscle Cell Differentiation Muscle Tissue Development Negative Regulation Of Cellular Metabolic Process Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Organ Development
Tagcloud ?		bound break chromatin cytoplasm damage dsb ectopic etoposide foci fractionation gammah2ax hcc hep3b hepatocellular huh ifnb l02 localization mumol null nutlin pifithrin pretreatment redistributed sensor smmc strand subcellular tp53	accumulating associates box compartment competition constitute developmentally e2a e47 enforced erythroid gal helix heterodimers hypermethylation implicates k562 lineages lymphoid metazoa overlapping shift specificities strict suggestive tal1 vicinity vp16
Tagcloud (Difference) ?		bound break chromatin cytoplasm damage dsb ectopic etoposide foci fractionation gammah2ax hcc hep3b hepatocellular huh ifnb l02 localization mumol null nutlin pifithrin pretreatment redistributed sensor smmc strand subcellular tp53	accumulating associates box compartment competition constitute developmentally e2a e47 enforced erythroid gal helix heterodimers hypermethylation implicates k562 lineages lymphoid metazoa overlapping shift specificities strict suggestive tal1 vicinity vp16
Tagcloud (Intersection) ?