IAPP and COL25A1

Number of citations of the paper that reports this interaction (PMID 15522881)
4

Data Source:
HPRD (in vitro)

		IAPP	COL25A1
Gene Name		islet amyloid polypeptide	collagen, type XXV, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Neuronal Cell Body	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Hormone Activity Identical Protein Binding	Beta-amyloid Binding Heparin Binding
	Biological Process	Apoptotic Process Signal Transduction Cell-cell Signaling Sensory Perception Of Pain Endocrine Pancreas Development Eating Behavior Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption	Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR G alpha (s) signalling events GPCR ligand binding Metabolic disorders of biological oxidation enzymes Amyloids GPCR downstream signaling Regulation of beta-cell development Regulation of gene expression in beta cells Calcitonin-like ligand receptors Class B/2 (Secretin family receptors)	Collagen formation Collagen degradation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		6 interactors: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	3 interactors: APP IAPP SNCA
Entrez ID		3375	84570
HPRD ID		01005	09886
Ensembl ID		ENSG00000121351	ENSG00000188517
Uniprot IDs		P10997	A8MWQ5 Q9BXS0
PDB IDs		1KUW 2G48 2KB8 2L86 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ
Enriched GO Terms of Interacting Partners?		Regulation Of Hormone Levels Peptide Hormone Processing Receptor Internalization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Enkephalin Processing Islet Amyloid Polypeptide Processing Regulation Of CAMP Metabolic Process Organ Senescence Peptide Metabolic Process Protein Localization To Plasma Membrane Detection Of Glucose Basement Membrane Assembly Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Hormone Metabolic Process Response To Chlorate Positive Regulation Of Protein Glycosylation Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Plasma Membrane Organization Response To Iron(II) Ion Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Protein Processing Response To Leucine Cellular Amide Metabolic Process Regulation Of Hormone Secretion Insulin Processing Exocrine Pancreas Development Vascular Smooth Muscle Cell Development Calcium Ion Transport Protein Autoprocessing Regulation Of Protein Glycosylation Positive Regulation Of Vasculogenesis Angiogenesis Insulin Metabolic Process Negative Regulation Of Vascular Permeability Receptor-mediated Endocytosis Transdifferentiation Protein Localization To Membrane Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Protein Transport Regulation Of Vasculogenesis Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Protein Secretion	Behavior Feeding Behavior Adult Locomotory Behavior Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Peptidase Activity Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Adult Behavior Synapse Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Synaptic Growth At Neuromuscular Junction Locomotory Behavior Dopamine Uptake Involved In Synaptic Transmission Collateral Sprouting In Absence Of Injury Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Proteolysis Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Iron(II) Ion Cellular Response To Copper Ion Negative Regulation Of Protein Processing Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Endopeptidase Activity Axon Choice Point Recognition Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Synaptic Vesicle Recycling Response To Oxidative Stress Single-organism Behavior Posttranscriptional Regulation Of Gene Expression Neuron Remodeling Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Oxidative Phosphorylation
Tagcloud ?		deficient drives metabolic p53 regression reprogramming tumor upregulation
Tagcloud (Difference) ?		deficient drives metabolic p53 regression reprogramming tumor upregulation
Tagcloud (Intersection) ?