APLP1 and DAB1

Number of citations of the paper that reports this interaction (PMID 10460257)
32

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		APLP1	DAB1
Gene Name		amyloid beta (A4) precursor-like protein 1	Dab, reelin signal transducer, homolog 1 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Cytosol Brush Border Postsynaptic Density Membrane Neuron Projection Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Transition Metal Ion Binding	Phosphatidylinositol 3-kinase Binding
	Biological Process	MRNA Polyadenylation Regulation Of Translation Endocytosis Apoptotic Process Cell Adhesion Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Nervous System Development Organ Morphogenesis Extracellular Matrix Organization Negative Regulation Of CAMP Biosynthetic Process Forebrain Development Cellular Response To Norepinephrine Stimulus	Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Midgut Development Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Radial Glia Guided Migration Of Purkinje Cell Response To Drug Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Lateral Motor Column Neuron Migration
Pathways
Drugs
Diseases
GWAS			Bulimia nervosa ( 23568457) Immune reponse to smallpox (secreted IL-10) ( 22610502) Kawasaki disease ( 21221998) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		43 interactors: ANXA7 APBB1 APBB3 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24	73 interactors: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CDK6 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM103A1 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MBNL1 MBNL3 MYO6 NAF1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR WDYHV1 ZBTB32 ZC3H10 ZCCHC10 ZNF488
Entrez ID		333	1600
HPRD ID		00102	04582
Ensembl ID		ENSG00000105290	ENSG00000173406
Uniprot IDs		F5GZ08 P51693	O75553
PDB IDs		3PMR 3Q7G 3Q7L 3QMK
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Anatomical Structure Development Positive Regulation Of Protein Metabolic Process System Development Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Multicellular Organismal Development Regulation Of Phosphorylation Response To Organic Substance Regulation Of Gene Expression Response To Copper Ion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Process Regulation Of Cell Proliferation Positive Regulation Of Protein Phosphorylation Cellular Aromatic Compound Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cell Death Regulation Of Kinase Activity Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Copper Ion Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of Growth Response To Growth Factor Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Growth Positive Regulation Of Cell Death Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Response To Organic Cyclic Compound Digestive Tract Development Negative Regulation Of Cellular Metabolic Process Cell Cycle Arrest RNA Metabolic Process Response To Inorganic Substance Regulation Of Cell Cycle Digestive System Development Negative Regulation Of Cell Growth G1/S Transition Of Mitotic Cell Cycle	Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Reelin-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Developmental Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Central Nervous System Development Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Nervous System Development Brain Development Regulation Of Cellular Protein Metabolic Process Gliogenesis Regulation Of Protein Metabolic Process Head Development Anatomical Structure Morphogenesis Response To External Stimulus Cell Surface Receptor Signaling Pathway Forebrain Development System Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Cellular Metabolic Process Organ Development Wound Healing Immune System Process Layer Formation In Cerebral Cortex Locomotion Neuron Projection Morphogenesis Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Signaling Endocytosis MRNA Processing Neurogenesis Cerebral Cortex Radial Glia Guided Migration
Tagcloud ?		abundance allocated analyzing aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing sv2 sv2a synaptic synaptogamin synaptophysin synaptotagmin vesicle zone	assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical
Tagcloud (Difference) ?		abundance allocated analyzing aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing sv2 sv2a synaptic synaptogamin synaptophysin synaptotagmin vesicle zone	assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical
Tagcloud (Intersection) ?