DNAJA1 and HMGCL

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DNAJA1	HMGCL
Gene Name		DnaJ (Hsp40) homolog, subfamily A, member 1	3-hydroxymethyl-3-methylglutaryl-CoA lyase
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Mitochondrion Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Peroxisome
	Molecular Function	G-protein Coupled Receptor Binding Protein Binding ATP Binding Hsp70 Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Receptor Binding Manganese Ion Binding Carboxylic Acid Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Protein Refolding DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport	Liver Development Leucine Catabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cellular Ketone Body Metabolic Process Ketone Body Biosynthetic Process Protein Tetramerization Response To Fatty Acid
Pathways			Ketone body metabolism Fatty acid, triacylglycerol, and ketone body metabolism Synthesis of Ketone Bodies Metabolism of lipids and lipoproteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LSM2 NELFCD NUDT3 PAXIP1 PTTG1 SUMO4 TM4SF1 TXN	8 interactors: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 MS4A7 PEX5 RNF126
Entrez ID		3301	3155
HPRD ID		04159	02003
Ensembl ID		ENSG00000086061	ENSG00000117305
Uniprot IDs		P31689	B1AK13 P35914
PDB IDs		2LO1 2M6Y	2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Negative Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination Nucleobase-containing Compound Metabolic Process Protein Polyubiquitination G2 DNA Damage Checkpoint Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Methylation Cell Cycle Checkpoint Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Voltage-gated Chloride Channel Activity Negative Regulation Of Fibril Organization Positive Regulation Of Histone H4-K16 Acetylation Diphosphoinositol Polyphosphate Catabolic Process Negative Regulation Of Potassium Ion Export Diadenosine Polyphosphate Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process DNA Repair Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Heart Rate By Hormone Positive Regulation Of Cellular Protein Metabolic Process	Protein Targeting Cellular Localization Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Cellular Protein Localization Protein Localization To Organelle Intracellular Transport Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Inhibition Of Neuroepithelial Cell Differentiation Negative Regulation Of Protein Homotetramerization Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Protein Import Into Peroxisome Matrix, Translocation Auditory Receptor Cell Fate Determination Trochlear Nerve Development Protein Import Protein Targeting To Membrane Protein Import Into Peroxisome Matrix, Docking Ascending Aorta Morphogenesis Positive Regulation Of Mitotic Cell Cycle, Embryonic Oculomotor Nerve Development Protein Localization Regulation Of Pro-B Cell Differentiation Regulation Of Auditory Receptor Cell Differentiation STAT Protein Import Into Nucleus Establishment Of Localization In Cell Negative Regulation Of Protein Homooligomerization Cell Motility Intracellular Protein Transport Regulation Of Forebrain Neuron Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Timing Of Neuron Differentiation Forebrain Radial Glial Cell Differentiation Comma-shaped Body Morphogenesis Establishment Of Protein Localization To Membrane Protein Import Into Peroxisome Membrane Common Bile Duct Development Protein To Membrane Docking Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Renal Interstitial Fibroblast Development DNA Damage Response, Detection Of DNA Damage Peroxisomal Membrane Transport S-shaped Body Morphogenesis Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
Tagcloud ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Difference) ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Intersection) ?