HOXA10 and SIRT2

Number of citations of the paper that reports this interaction (PMID 15213244)
15

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		HOXA10	SIRT2
Gene Name		homeobox A10	sirtuin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm	Nucleus Chromatin Silencing Complex Chromosome Nuclear Heterochromatin Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Plasma Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Histone Deacetylase Binding	Chromatin Binding NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Beta-tubulin Binding NAD+ Binding
	Biological Process	Skeletal System Development Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Uterus Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Chromatin Silencing Chromatin Silencing At Telomere Transcription, DNA-templated Protein ADP-ribosylation Protein Deacetylation Autophagy Mitotic Nuclear Division Regulation Of Exit From Mitosis Negative Regulation Of Cell Proliferation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Phosphatidylinositol 3-kinase Signaling Gene Silencing Histone Deacetylation Substantia Nigra Development Myelination In Peripheral Nervous System Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Protein Kinase B Signaling Cellular Lipid Catabolic Process Innate Immune Response Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Hepatocyte Growth Factor Receptor Signaling Pathway Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Caloric Restriction Negative Regulation Of Oligodendrocyte Progenitor Proliferation Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Molecule Of Bacterial Origin Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Defense Response To Bacterium Ripoptosome Assembly Involved In Necroptotic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Pathways
Drugs
Diseases
GWAS		Dental caries ( 23259602)
Protein-Protein Interactions		12 interactors: CREBBP EMX1 EP300 FOXO1 GMNN MEIS1 PBX1 POLR3D PTPN6 SIRT2 SNAPC1 SPI1	13 interactors: CDC14B CDC20 EP300 FZR1 HDAC6 HIST1H3A HOXA10 KAT2A KAT2B SP140 TUBA4A TUBB XPO1
Entrez ID		3206	22933
HPRD ID		00845	10377
Ensembl ID		ENSG00000253293	ENSG00000068903
Uniprot IDs		P31260	Q8IXJ6
PDB IDs			1J8F 3ZGO 3ZGV
Enriched GO Terms of Interacting Partners?		Immune System Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Nitrogen Compound Metabolic Process Cell Development Protein Acetylation Negative Regulation Of Cell Differentiation N-terminal Peptidyl-lysine Acetylation Stem Cell Maintenance Positive Regulation Of Transcription, DNA-templated Innate Immune Response Organ Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Morphogenesis Gene Expression Multicellular Organismal Development Stem Cell Development Regulation Of Gene Expression Peptidyl-lysine Modification Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Positive Regulation Of Type I Interferon Production Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation N-terminal Protein Amino Acid Acetylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune Response Developmental Process Regulation Of Type I Interferon Production Negative Regulation Of Gene Expression System Development Defense Response	Activation Of Anaphase-promoting Complex Activity Cell Cycle Organelle Organization Cell Cycle Process N-terminal Peptidyl-lysine Acetylation Chromatin Organization Mitotic Cell Cycle Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ubiquitin-protein Transferase Activity Chromosome Organization Peptidyl-lysine Modification Positive Regulation Of Ligase Activity Chromatin Modification Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Metabolic Process N-terminal Protein Amino Acid Acetylation Mitotic Cell Cycle Process Histone Acetylation G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Positive Regulation Of Gluconeogenesis Negative Regulation Of Cellular Metabolic Process Histone Modification Protein Acetylation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Cycle N-terminal Protein Amino Acid Modification Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Response To Stress Chromatin Remodeling Positive Regulation Of Glucose Metabolic Process G2 DNA Damage Checkpoint Viral Process Regulation Of Protein Ubiquitination Histone H3-K9 Modification Cell Cycle Checkpoint Regulation Of Meiosis Histone H3 Acetylation Regulation Of Gluconeogenesis Anterior/posterior Pattern Specification Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition
Tagcloud ?		contrary coordination definitive drives e2 elevate epigenetic eralpha ere ere1 ere2 eres extensively h3k4 haematopoiesis homeobox knockdown leukaemia lineage methylase mll mll1 much oestrogen recruiting start suppresses transcriptionally way	3t3 acbd3 acetylated acetylation acyl adipocytes anchoring cargos coa comprising deacetylated disposal endosomes enhances exocytic glut4 golgin gsv gsvs irap l1 nad recycles redistributed triggers tug unstimulated vesicles wildtype
Tagcloud (Difference) ?		contrary coordination definitive drives e2 elevate epigenetic eralpha ere ere1 ere2 eres extensively h3k4 haematopoiesis homeobox knockdown leukaemia lineage methylase mll mll1 much oestrogen recruiting start suppresses transcriptionally way	3t3 acbd3 acetylated acetylation acyl adipocytes anchoring cargos coa comprising deacetylated disposal endosomes enhances exocytic glut4 golgin gsv gsvs irap l1 nad recycles redistributed triggers tug unstimulated vesicles wildtype
Tagcloud (Intersection) ?