HLA-DQA1 and LRIF1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HLA-DQA1	LRIF1
Gene Name		major histocompatibility complex, class II, DQ alpha 1	ligand dependent nuclear receptor interacting factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Nucleus Microtubule Organizing Center Actin Cytoskeleton Nuclear Matrix
	Molecular Function	MHC Class II Receptor Activity Peptide Antigen Binding	Protein Binding Retinoic Acid Receptor Binding
	Biological Process	Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of T Cell Differentiation T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Asthma ( 23181788) Celiac disease ( 20190752 17558408) Cervical cancer ( 23482656) Chronic lymphocytic leukemia ( 21131588) Crohn's disease ( 23266558) Hepatocellular carcinoma ( 22807686) Hypothyroidism ( 22493691) Immune response to anthrax vaccine ( 22658931) Inflammatory bowel disease ( 18758464) Leishmaniasis (visceral) ( 23291585) Lymphoma ( 23349640) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nephropathy (idiopathic membranous) ( 21323541) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 21653640) Schizophrenia ( 23212062 19571809) Systemic lupus erythematosus ( 18204098 21408207) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23128233 21297633 19122664 23511034) Vitiligo ( 20410501)
Protein-Protein Interactions		8 interactors: APLP1 CD74 CDK7 IKBKG LRIF1 SH3GL2 TLE1 UNC119	129 interactors: AKR1C3 ANKRD24 ANXA1 ANXA7 APLP1 ARL3 ATF3 ATP1B1 BARD1 BMI1 BOC BRD7 BRMS1 CALR CBX1 CBX5 CCDC106 CDC42 CDKN1A CDKN2C CETN3 CHD3 CKMT2 COX17 CPE CRADD CRCT1 DDIT4 EIF6 ESR1 ETHE1 FAS FEZ1 FXR1 GADD45G GC GIT1 GPRASP2 GSTM4 HAP1 HIST3H3 HLA-DQA1 HMGB1 HMOX2 HSPB1 HSPB3 HSPBP1 HSPE1 ID2 IMMT KAT5 KAT7 KBTBD7 KCNE3 KLHL20 KLK10 LAMA4 LAMTOR5 MAD2L1BP MLLT3 MNAT1 MOB4 MPHOSPH6 MRPS12 MRPS6 NACA NHP2L1 NOC2L NR3C1 NRBP1 PAEP PAFAH1B3 PCDHA4 PDCD5 PFDN1 PFN1 PIAS4 PIN1 PLEKHA4 PNP POLR2C POLR3F PPARG PQBP1 PRMT1 PSG9 PSMD11 PSMD2 PSPC1 RAB27A RAP1B RARA RBM5 RCC1 RFC5 RHOH RIT1 RNF10 RORA RPA2 RPL37A RPLP1 RRM1 S100A8 SAT1 SELENBP1 SERPINB9 SETDB1 SMN1 SNRPN SPG7 STX5 SULT1E1 SUPT4H1 SUV39H2 TAF1D TDGF1 TGIF1 THRB TK1 TRBV2 TRDMT1 TSC22D1 TSPAN6 UBE2V2 VIM WDR62 WWC1 ZNF24
Entrez ID		3117	55791
HPRD ID		06765	17975
Ensembl ID		ENSG00000196735	ENSG00000121931
Uniprot IDs		B7ZW51 L8E864 P01909 Q08AS3 Q30063 Q5Y7H0 Q8MH44	Q5T3J3
PDB IDs		1JK8 1NBN 1S9V 1UVQ 2NNA 4GG6
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Signaling Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Clathrin-mediated Endocytosis Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Signaling Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Protein Kinase Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Kinase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Phosphorylation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Transferase Activity Negative Regulation Of Caveolin-mediated Endocytosis Cellular Response To Stimulus Activation Of MAPK Activity Cytokinesis, Completion Of Separation Cellular Response To Norepinephrine Stimulus Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Mature B Cell Apoptotic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Endocytosis RNA Metabolic Process Response To Norepinephrine Intracellular Receptor Signaling Pathway Establishment Of Vesicle Localization Regulation Of Peptidyl-tyrosine Phosphorylation Vesicle Localization Positive Regulation Of MAP Kinase Activity Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Gene Expression Mitotic Cytokinetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Protein Metabolic Process System Development Regulation Of Gene Expression Developmental Process Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Multicellular Organismal Development Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Anatomical Structure Development Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Nervous System Development Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Macromolecule Biosynthetic Process Response To Organic Substance Cellular Metabolic Process Response To Stress Positive Regulation Of Apoptotic Process Response To Steroid Hormone Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus DNA-templated Transcription, Initiation Regulation Of Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Organic Substance Regulation Of Cell Cycle
Tagcloud ?			aging apply characterizing composition dysfunctional enrich immunopurified involves isolation isotope labelling polypeptides pot1 qtip shelterin shelterins silac smchd1 states syndromes telomere telomeres telomeric tho tin2 tpp1 trf1 tumourigenesis validate
Tagcloud (Difference) ?			aging apply characterizing composition dysfunctional enrich immunopurified involves isolation isotope labelling polypeptides pot1 qtip shelterin shelterins silac smchd1 states syndromes telomere telomeres telomeric tho tin2 tpp1 trf1 tumourigenesis validate
Tagcloud (Intersection) ?