HIF1A and JUN

Number of citations of the paper that reports this interaction (PMID 11739718)
15

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HIF1A	JUN
Gene Name		hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	jun proto-oncogene
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol Motile Cilium RNA Polymerase II Transcription Factor Complex	Nuclear Chromosome Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytosol Transcriptional Repressor Complex
	Molecular Function	Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Rho GTPase Activator Activity Protein Binding Transcription Factor Binding Enzyme Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding R-SMAD Binding HMG Box Domain Binding
	Biological Process	Angiogenesis Response To Hypoxia Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Neuroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Transcription, DNA-templated Cellular Iron Ion Homeostasis Signal Transduction Notch Signaling Pathway Lactation Visual Learning Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Receptor Biosynthetic Process Response To Muscle Activity Axon Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Embryonic Hemopoiesis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Hemoglobin Biosynthetic Process Glucose Homeostasis MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Nitric-oxide Synthase Activity Cartilage Development Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Retina Vasculature Development In Camera-type Eye Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process	Angiogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Liver Development Positive Regulation Of Endothelial Cell Proliferation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Aging Learning Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Response To Mechanical Stimulus Monocyte Differentiation Axon Regeneration Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Rho GTPase Activity Response To Lipopolysaccharide Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Leading Edge Cell Differentiation TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Response To Hydrogen Peroxide Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Innate Immune Response Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Potassium Ion Starvation Stress-activated MAPK Cascade Response To CAMP Regulation Of Cell Cycle Membrane Depolarization SMAD Protein Signal Transduction Cellular Response To Calcium Ion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Pre-NOTCH Transcription and Translation MyD88 dependent cascade initiated on endosome Pre-NOTCH Expression and Processing TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signaling by NOTCH TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs			Vinblastine Irbesartan Arsenic trioxide
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		67 interactors: APEX1 AR ARNT ARNT2 ARNTL ATM CDC34 CDKN2A CITED2 COPS5 CREBBP CSNK2A1 CTNNB1 DAP3 EGLN1 EGLN2 EGLN3 EP300 FHL2 GNB2L1 HDAC1 HDAC2 HDAC5 HIF1AN HIF3A HSP90AA1 HSP90AB1 JUN MAFG MAFK MAPK1 MAPK3 MAX MCM7 MDM2 MTA1 NAA10 NAA11 NCOA1 NCOA2 NDN NR4A1 OS9 PER1 PGK1 PKM PLD1 PSMA7 RB1 RUNX2 RWDD3 SAT1 SEPT9 SP1 SSX4 STAT3 STUB1 SUMO1 SUMO2 TP53 TRAF6 TSGA10 UBE2D1 USP19 USP20 VHL VHLL	185 interactors: ABL1 APLP2 APP AR ARRB1 ASCC1 ASCC2 ASCC3 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BATF3 BBS7 BCL3 BCL6 BRCA1 CASP9 CEBPE CEBPG CLINT1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CREB3 CREB5 CREBBP CSNK2A1 CSNK2A2 CSNK2B DACH1 DDIT3 DDX21 DHX9 EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSL1 FOSL2 GATA2 GOPC GPS1 GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFATC2 NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RFWD2 RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBE2I VAV1 VDR
Entrez ID		3091	3725
HPRD ID		04517	01302
Ensembl ID		ENSG00000100644	ENSG00000177606
Uniprot IDs		A8MYV6 D0VY79 Q16665	P05412
PDB IDs		1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J	1A02 1FOS 1JNM 1JUN 1S9K 1T2K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Cellular Metabolic Process Cellular Response To Hypoxia Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen Levels Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Response To Abiotic Stimulus Biosynthetic Process Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Response To Hypoxia Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Gene Expression Response To Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Response To Growth Factor	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Developmental Process Cellular Response To Stress Cell Differentiation Multicellular Organismal Development Response To Organic Substance Anatomical Structure Development Response To Stress Organ Development Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance System Development DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1	acidic administered adulthood artificial biased ca3 cerebrospinal counting delayed excitotoxins fibrillary glial immediate intracerebroventricular ka kainic limbic neuronal neuropsychiatric neurotoxicity nmol p14 p45 p7 p75 perhaps preweanling produce subfield
Tagcloud (Difference) ?		actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1	acidic administered adulthood artificial biased ca3 cerebrospinal counting delayed excitotoxins fibrillary glial immediate intracerebroventricular ka kainic limbic neuronal neuropsychiatric neurotoxicity nmol p14 p45 p7 p75 perhaps preweanling produce subfield
Tagcloud (Intersection) ?