ANXA6 and CR2

Number of citations of the paper that reports this interaction (PMID 1831222)
1

Data Source:
HPRD (in vitro)

		ANXA6	CR2
Gene Name		annexin A6	complement component (3d/Epstein Barr virus) receptor 2
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Focal Adhesion Membrane Late Endosome Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding GTP Binding Calcium-dependent Phospholipid Binding Lipid Binding Ligand-gated Ion Channel Activity Cholesterol Binding Protein Homodimerization Activity Calcium-dependent Protein Binding	Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Homodimerization Activity
	Biological Process	Calcium Ion Transport Regulation Of Muscle Contraction Ion Transmembrane Transport Protein Homooligomerization	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation Innate Immune Response
Pathways
Drugs
Diseases
GWAS			Type 2 diabetes ( 21490949)
Protein-Protein Interactions		9 interactors: A2M CDC73 CR2 MLH1 RASA1 S100A1 S100B SNCA TPD52	10 interactors: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53
Entrez ID		309	1380
HPRD ID		00231	00399
Ensembl ID		ENSG00000197043	ENSG00000117322
Uniprot IDs		A6NN80 P08133	P20023
PDB IDs		1M9I	1GHQ 1LY2 1W2R 1W2S 2GSX 3OED
Enriched GO Terms of Interacting Partners?		Developmental Process Cell Activation Leukocyte Activation B Cell Activation Cell Differentiation Protein Destabilization Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Cellular Response To Stimulus Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Meiotic Metaphase I Plate Congression Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Meiotic Spindle Midzone Assembly MRNA 3'-end Processing Lymphocyte Activation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Calcium Ion Transport Immune System Process B Cell Differentiation RNA 3'-end Processing Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Mitotic Recombination Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Synaptic Transmission Immune Response Regulation Of Immune System Process Signaling Cell Communication Negative Regulation Of Dopamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Cellular Respiration Regulation Of Protein Stability Response To Stimulus Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Skeletal Muscle Cell Differentiation System Development Regulation Of Cell Shape Regulation Of Synaptic Plasticity Protein Activation Cascade Regulation Of Signal Transduction	Regulation Of Immune Response Regulation Of Humoral Immune Response Immune Response Regulation Of Immune System Process Innate Immune Response Positive Regulation Of Humoral Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of Complement Activation Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immune Response Humoral Immune Response Defense Response Adaptive Immune Response T Cell Activation Involved In Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process B Cell Differentiation Negative Regulation Of Macromitophagy Negative Regulation Of Complement Activation, Alternative Pathway Oligodendrocyte Apoptotic Process Positive Regulation Of Type IIa Hypersensitivity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Lymphocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Leukocyte Proliferation Negative Regulation Of Helicase Activity Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Notch Signaling Pathway Complement Activation Signal Transduction Negative Regulation Of Complement Activation, Classical Pathway Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Leukocyte Activation Involved In Immune Response B Cell Activation Defense Response To Virus Complement Receptor Mediated Signaling Pathway CRD-mediated MRNA Stabilization Protein Activation Cascade
Tagcloud ?		1q21 5q31 6p21 alleles applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic prkra psoriasis rarely shared th2 tnip1 traits unreported utilizing	abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v
Tagcloud (Difference) ?		1q21 5q31 6p21 alleles applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic prkra psoriasis rarely shared th2 tnip1 traits unreported utilizing	abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v
Tagcloud (Intersection) ?