HGF and ADAMTSL4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		HGF	ADAMTSL4
Gene Name		hepatocyte growth factor (hepapoietin A; scatter factor)	ADAMTS-like 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Cellular_component Interstitial Matrix Endoplasmic Reticulum Lumen
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Protein Heterodimerization Activity	Protease Binding Metalloendopeptidase Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Epithelial To Mesenchymal Transition Liver Development Platelet Degranulation Proteolysis Mitotic Nuclear Division Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Hyaluronan Metabolic Process Positive Regulation Of Cell Migration Organ Regeneration Positive Regulation Of Myelination Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Myoblast Proliferation Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Neuron Projection Regeneration Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of DNA Biosynthetic Process	Protein O-linked Glycosylation Proteolysis Apoptotic Process Extracellular Matrix Organization Protein O-linked Fucosylation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Signaling by Interleukins Response to elevated platelet cytosolic Ca2+ Interleukin-7 signaling Cytokine Signaling in Immune system Platelet degranulation Platelet activation, signaling and aggregation	Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs		O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		16 interactors: ADAMTSL4 BRCA1 CLEC3B F11 FN1 HGFAC HPN KLKB1 LCN2 MEOX2 MET PLAU SDC1 SDC2 ST14 VTN	106 interactors: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 C19orf66 C6orf165 CATSPER1 CCDC26 CHCHD2 CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL1P1 GNE GNMT GOLGA8EP HGF HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587
Entrez ID		3082	54507
HPRD ID		00799	18237
Ensembl ID		ENSG00000019991	ENSG00000143382
Uniprot IDs		P14210	F8WAD0 Q6UY14 Q9UFG7
PDB IDs		1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4K3J
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Positive Regulation Of Protein Processing Regulation Of Blood Coagulation Regulation Of Wound Healing Wound Healing Positive Regulation Of Fibrinolysis Response To Wounding Positive Regulation Of Plasminogen Activation Positive Regulation Of Protein Metabolic Process Plasminogen Activation Protein Metabolic Process Proteolysis Extracellular Matrix Disassembly Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Tissue Development Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Processing Regulation Of Cellular Component Organization Blood Coagulation Hemostasis Fibrinolysis Detection Of Abiotic Stimulus Multicellular Organismal Development Regulation Of Protein Metabolic Process Endodermal Cell Differentiation Anatomical Structure Development Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Cell Death Regulation Of Body Fluid Levels Death Anatomical Structure Morphogenesis Response To Abiotic Stimulus Endoderm Formation Glycosaminoglycan Catabolic Process Embryo Development Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Chondroitin Sulfate Metabolic Process Response To External Stimulus Developmental Process Response To Stimulus Regulation Of Acute Inflammatory Response Acute Inflammatory Response	Multicellular Organismal Development Keratinization Organ Development Developmental Process Keratinocyte Differentiation System Development Anatomical Structure Development Epidermis Development Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Cell Differentiation Sensory Organ Development Response To Organic Substance Organic Anion Transport Positive Regulation Of Neuron Projection Regeneration Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Cellular Response To Thyroid Hormone Stimulus MRNA Transcription From RNA Polymerase II Promoter Skin Development Positive Regulation Of Transcription, DNA-templated Transepithelial Transport Semicircular Canal Development Positive Regulation Of Gene Expression Regulation Of Branching Involved In Salivary Gland Morphogenesis MRNA Transcription Response To Thyroid Hormone Negative Regulation Of Hydrolase Activity Cell Differentiation Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?		amifostine anticancer benefits csf cytoprotective decitabine demethylating developments emerging gm granulocyte hematologic hematopoietic hgfs improvements includes infectious introduced issues keratinocyte kgf prophylactic renewed risks supportive thrombopoietin topics transfusional transfusions	abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Difference) ?		amifostine anticancer benefits csf cytoprotective decitabine demethylating developments emerging gm granulocyte hematologic hematopoietic hgfs improvements includes infectious introduced issues keratinocyte kgf prophylactic renewed risks supportive thrombopoietin topics transfusional transfusions	abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Intersection) ?